Results 41 to 50 of about 11,983 (279)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Surface and subsurface structural response on the City of London cable tunnels project [PDF]

, 2001
This paper presents surface and subsurface ground and structural response to the excavation of an urban cable tunnel within London clay and the Lambeth Group strata.
Bloodworth, Alan G., Legge, N. B.
core  

Future in Wood? Timber Construction in Boosting Local Development [PDF]

, 2016
Large scale timber construction has been on the upswing for some time in many European countries. Besides the building cluster, also regions and cities have taken advantage of the ongoing timber boom in their economic and spatial development.
Hynynen, Ari
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

From basements and foundations to leading modern scientific school

Bulletin of Prydniprovs’ka State Academy of Civil Engineering and Architecture, 2017
Постановка проблеми. Оскільки все починається з основ, як у філософському, так і у будівельному сенсі, кафедра основ і фундаментів була невід'ємною складовою формування Дніпропетровського інженерно-будівельного інституту. За своє 85-річне існування вона була рефлексією розвитку рідного інституту, згодом академії, а також будівельної галузі в цілому ...
Sedin, V. L., Bikus, K. M.
openaire   +1 more source

Correlation of geotechnical parameters with geological formations in a basement complex and its implications on civil structure foundation

International Journal of Physical Sciences, 2018
Geotechnical tests were carried out on twenty subsoil samples obtained from ten locations at the depth of 1 and 2 m within Federal University of Technology, Akure, Nigeria. The area is typical of basement complex. The test include; Natural Moisture Content, Grain Size Analyses, Specific Gravity, Atterberg Limits, Compaction, California Bearing Ratio ...
O. J. Akintorinwa, S. T. Oluwole
openaire   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Mechanoregulatory Effects of Cell‐Scale Microwells on Epithelial Cell Phenotype

Advanced Functional Materials, EarlyView.
In small polycaprolactone microwells, A549 epithelial cells span well edges, in contrast to cells growing on flat substrates. Focal adhesion sites (yellow) concentrate at topographic boundaries, while cytoskeletal tension (magenta stress fibers) is transmitted to the nucleus (blue), reducing nuclear sphericity.
Ruiwen He, Wang Sik Lee, Phattadon Yajan, Aaron Lee, Mauro Sousa de Almeida, Sandeep Keshavan, Jozef Adamcik, Céline Loussert‐Fonta, Dimitri Vanhecke, Barbara Rothen‐Rutishauser, Alke Petri‐Fink   +10 more
wiley   +1 more source

A concerted and multi-criterion approach for helping to choose a Structure- Foundation system of building [PDF]

, 2004
The research of the best building design requires a concerted design approach of both structure and foundation. Our work is an application of this approach.
Al Diab, Ali, Boulemia, Cherif, Henry, Eric   +2 more
core  

An Engineered Living Material With Pro‐Angiogenic Activity Inducible by Near‐Infrared Light

Advanced Functional Materials, EarlyView.
NIR‐responsive engineered living materials (ELMs) for controlled angiogenesis: Near‐infrared (800 nm) light activates engineered probiotic bacteria within alginate‐based living materials to secrete a blood vessel‐regenerating protein. The released protein promotes pro‐angiogenic effects in endothelial networks and chick chorioallantoic membranes.
Anwesha Chatterjee, Stefanie S. M. Meier, Sara Trujillo, Andreas Möglich, Shrikrishnan Sankaran   +4 more
wiley   +1 more source