Results 171 to 180 of about 21,994 (213)

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease

Brain Pathology, EarlyView.
Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

A grounded theory of the process of social transition in a family context from the perspective of gender diverse young people and their parents

Child and Adolescent Mental Health, EarlyView.
Background Some gender diverse young people (GDYP) socially transition—a process of changing from living as the gender that they were assigned at birth to another gender, through social means. Whilst the role of the whole family in the social transitions of GDYP has been indicated, there is a lack of applicable theory and research on the processes of ...
Sophie Razzel, Simon Levinson, Trish Joscelyne   +2 more
wiley   +1 more source

Manoeuvring Among Institutions and Pandemic Restrictions: When the Fantasy of Parenting After Divorce or Breakup and the Respective Emotions Matter

Child &Family Social Work, EarlyView.
ABSTRACT Understanding social factors that affected how people interpreted the meanings of COVID‐19 measures is important in postpandemic times. This study applies perspectives from research on emotions as one of the possible explanations and focuses on how institutions and their measures are perceived in the context of individual emotional situations.
Eva M. Hejzlarová
wiley   +1 more source

Supervision as a Dispersed Practice: Exploring the Creation of Supervisory Spaces in Day‐to‐Day Social Work Practice

Child &Family Social Work, EarlyView.
ABSTRACT Supervision is integral to social work practice; however, how it operates in day‐to‐day practice remains poorly understood. Existing research mainly comprises quantitative and qualitative accounts of social workers' and supervisors' experiences of supervision.
Mark Gregory
wiley   +1 more source

‘Talk to Us, Not About Us’: Children's Understandings and Experiences of Participation in Australian Family Law

Child &Family Social Work, EarlyView.
ABSTRACT A hive of recent policy and legislative activity in Australian family law has emphasized the importance of children's right to participate in decision‐making following parental separation. Yet a powerful tension persists between supporting children's right to participation and protecting children from parental conflict.
Georgina Dimopoulos, Eliza Hew, Meaghan Vosz, Helen Walsh   +3 more
wiley   +1 more source

Empowering Children in Coping With Their Parents' Separation: The Views of Young Adults Looking Back on Their Childhood Experiences

Child &Family Social Work, EarlyView.
ABSTRACT Parental separation is a process that impacts children's lives before parents decide to separate, during the physical separation and in the adjustment that follows, which may continue for many years. This study draws on the retrospective accounts of 30 young adults (aged 18–30) who experienced parental separation in childhood, to identify what
Susan Kay‐Flowers
wiley   +1 more source

Relational Wellbeing Amongst Care‐Experienced Young People in Transition in the Context of Covid 19

Child &Family Social Work, EarlyView.
ABSTRACT Care‐experienced young people typically negotiate the transition to adulthood at a younger age than their peers in the general population and with less reliable access to support. Concerns have been raised that Covid 19 exacerbated the challenges they faced and widened the ‘care‐gap’.
Emily R. Munro, Seana Friel, Amy Lynch
wiley   +1 more source

Disseny d'un model de selecció comú per al personal de l'administració de la Generalitat i de les entitats locals de Catalunya [PDF]

, 2011
Aldomà i Buixadé, Josep, Boltaina Bosch, Xavier, Comellas Batet, Eva, Escola d'Administració Pública de Catalunya, Férez Fernández, Manuel, Gala Durán, Carolina, Miró Folgado, Lola, Payola Planella, Adriana, Valls Arnau, Joaquim   +8 more
core   +1 more source

Divorcescapes: Family Conflicts and Children's Lived Spaces

Child &Family Social Work, EarlyView.
ABSTRACT This article presents an analysis from a project that focuses on the entanglements that emerge between practices within the family law system and the everyday lives of children in conflictual family law cases. We position our analysis in critical childhood studies and zoom in on the social–spatial dimensions of children's everyday lives by ...
Hanne Warming, Sarah Alminde
wiley   +1 more source