Results 11 to 20 of about 5,700 (203)

A Single Nucleotide Polymorphism in the Il17ra Promoter Is Associated with Functional Severity of Ankylosing Spondylitis. [PDF]

PLoS ONE, 2016
The aim of this study was to identify new genetic variants associated with the severity of ankylosing spondylitis (AS). We sequenced the exome of eight patients diagnosed with AS, selected on the basis of the severity of their clinical parameters.
Jose Ramón Vidal-Castiñeira, Antonio López-Vázquez, Roberto Diaz-Peña, Paula Diaz-Bulnes, Pablo Martinez-Camblor, Eliecer Coto, Pablo Coto-Segura, Jacome Bruges-Armas, Jose Antonio Pinto, Francisco Jose Blanco, Alejandra Sánchez, Juan Mulero, Ruben Queiro, Carlos Lopez-Larrea   +13 more
doaj   +9 more sources

Both baseline clinical factors and genetic polymorphisms influence the development of severe functional status in ankylosing spondylitis. [PDF]

PLoS ONE, 2012
Functional severity in ankylosing spondylitis (AS) patients is variable and difficult to predict early. The aim of our study was to assess whether a combination of baseline clinical factors and genetic markers may predict the development of severe ...
Ruxandra Schiotis, Nerea Bartolomé, Alejandra Sánchez, Magdalena Szczypiorska, Jesús Sanz, Eduardo Cuende, Eduardo Collantes Estevez, Antonio Martínez, Diego Tejedor, Marta Artieda, Anca Buzoianu, Juan Mulero   +11 more
doaj   +5 more sources

Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts [PDF]

, 2012
The availability of population-specific normative data regarding disease severity measures is essential for patient assessment. The goals of the current study were to characterize the pattern of ankylosing spondylitis (AS) in Portuguese patients and to develop reference centile charts for BASDAI, BASFI, BASMI and mSASSS, the most widely used assessment
M. Pimentel-Santos, F., Mourão, Ana Filipa, Ribeiro, Célia, Costa, J. A., Santos, Helena, Barcelos, A., Pinto, Patricia, Godinho, F., Cruz, Margarida, Vieira-Sousa, Elsa, Santos, Rui André, Rabiais, Sara, Félix, Jorge, Fonseca, J. E., Guedes-Pinto, Henrique, Brown, Matthew A., De Matos, A. A., Ribeiro, C., Bravo Pimentão, J., Mateus, M., Nero, P., Araújo, P., Falcão, S., Pinto, T. L., Castelão, W., Vieira De Sousa, E., Caetano-Lopes, J., Silva, C., Simões, E., Madeira, H., Vaz Patto, J., Ferreira, J., Micaelo, M., Mediavilla, M. J., Sousa, M., Soares Branco, P., Godinho, F., Canas Da Silva, J., Garcês, S., Tavares, V., Ribeiro, A., Araújo, D., Costa, J. A., Costa, L., Afonso, M. C., Bogas, M., Alcino, S., Pinto, P., Cravo, A. R., Sequeira, G., Santos, R. A., Barcelos, A., Cunha, I., Cruz, M.   +53 more
openaire   +4 more sources

The effect of three years of TNF alpha blocking therapy on markers of bone turnover and their predictive value for treatment discontinuation in patients with ankylosing spondylitis: a prospective longitudinal observational cohort study [PDF]

, 2012
INTRODUCTION: The aim of this study was to investigate the effect of three years of tumor necrosis factor-alpha (TNF-alpha) blocking therapy on bone turnover as well as to analyze the predictive value of early changes in bone turnover markers (BTM) for ...
Arends, S., Bos, R., Brouwer, E., Groen, H., Houtman, P.M., Kallenberg, C.G., Leijsma, M.K., Spoorenberg, A., van der Veer, E.   +8 more
core   +15 more sources

Robot-Assisted Stereotactic Osteotomy Technique for Correcting Thoracolumbar Kyphotic Deformity in Ankylosing Spondylitis: A Technical Note. [PDF]

Orthop Surg
The robot‐assisted stereotactic osteotomy (RASO) technique enables quantitative wedge planning and reproducible stereotactic execution for rigid ankylosing spondylitis–related kyphotic deformity, demonstrating technical feasibility and acceptable perioperative safety.
Huang Y, Fan Y, Yu H, Wang Z, Ma Z, Wang T, Hu W, Zhang X, Zheng G, Wang Q, Wang Y.   +10 more
europepmc   +2 more sources

Sustained low functional impairment in axial spondyloarthritis (axSpA): which are the primary outcomes that should be targeted to achieve this?

Arthritis Research & Therapy, 2023
Objectives To (i) determine whether sustained disease activity states, as measured by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS), impact function, and (ii) evaluate ...
Walter P. Maksymowych, Robert D. Inman, Louis Bessette, Proton Rahman, Emmanouil Rampakakis, Odalis Asin-Milan, Meagan Rachich, Anne Marilise Marrache, Allen J. Lehman   +8 more
doaj   +1 more source

Assessment of functional disability and quality of life in patients with ankylosing spondylitis [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2009
Introduction Ankylosing spondylitis is a chronic progressive autoimmune inflammatory disorder involving mainly the axial skeleton and larger peripheral joints that progressively limits spinal mobility and may lead to irreversible structural changes and ...
Mustur Dušan, Vesović-Potić Vladislava, Stanisavljević Dejana, Ille Tatjana, Ille Mihailo   +4 more
doaj   +1 more source

Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts [PDF]

Clinical Rheumatology, 2011
The availability of population-specific normative data regarding disease severity measures is essential for patient assessment. The goals of the current study were to characterize the pattern of ankylosing spondylitis (AS) in Portuguese patients and to develop reference centile charts for BASDAI, BASFI, BASMI and mSASSS, the most widely used assessment
Pimentel-Santos, Fernando M., Mourao, Ana Filipa, Ribeiro, Celia, Costa, Jose, Santos, Helena, Barcelos, Anabela, Pinto, Patricia, Godinho, Fatima, Cruz, Margarita, Vieira Sousa, Elsa, Santos, Rui Andre, Rabiais, Sara, Felix, Jorge, Fonseca, Joao Eurico, Guedes-Pinto, Henrico, Brown, Matthew A., Branco, Jaime C., CORPOREA Study Group   +17 more
openaire   +5 more sources

Efficacy and safety of ixekizumab through 52 weeks in two phase 3, randomised, controlled clinical trials in patients with active radiographic axial spondyloarthritis (COAST-V and COAST-W). [PDF]

, 2020
OBJECTIVES: To investigate the efficacy and safety of ixekizumab for up to 52 weeks in two phase 3 studies of patients with active radiographic axial spondyloarthritis (r-axSpA) who were biological disease-modifying antirheumatic drug (bDMARD)-naive ...
Baraliakos, X., Bertram, C.C., Bosch, F. van den, Carlier, H., COAST-V Study Grp, COAST-W Study Grp, Deodhar, A., Dougados, M., Ermann, J., Gallo, G., Gensler, L.S., Heijde, D. van der, Landewe, R., Li, X.Q., Maksymowych, W.P., Sieper, J., Tomita, T., Walsh, J.A., Wei, J.C.C., Zhao, F.Y.   +19 more
core   +3 more sources

Impact of disease outcomes on the Assessment of SpondyloArthritis International Society Health Index (ASAS HI): a Bayesian network analysis of the DESIR cohort

RMD Open, 2023
Objective The objective of this study is to build a structural model visualising and quantifying the interrelationships of different disease outcomes with the Assessment of SpondyloArthritis International Society Health Index (ASAS HI) in patients with ...
Sofia Ramiro, Robert Landewé, Désirée van der Heijde, Maxime Dougados, Annelies Boonen, Jürgen Braun, Uta Kiltz, Imke Redeker   +7 more
doaj   +1 more source