Results 141 to 150 of about 1,150,117 (291)

Functional disability and its associated factors among community- dweller older adults living in Gondar Town, Ethiopia: a community-based cross-sectional study

BMC Public Health
Background Functional disability is an emerging public health concern that has an impact on the health and quality of life of older adults. If functional disability recognized early, it will be possible to support them to live independently.
Mihret Dejen Takele, Getachew Azeze Eriku, Destaw Marie Merawie, Fiseha Sefiwu Zinabu, Molla Fentanew, Gashaw Jember Belay, Alemu Kassaw Kibret   +6 more
doaj   +1 more source

Age-adjusted health conditions, frailty, and functionality among older adults in primary care

O Mundo da Saúde
This study aimed to investigate the relationship between health conditions, frailty, functionality, and age-adjusted scores among older adults receiving primary care services.
Patrícia Oliveira, Claudinéia Matos de Araújo Gesteira, Claudio Henrique Meira Mascarenhas, Ana Elza Oliveira de Mendonça, Elaine dos Santos Santana, Rodrigo Mercês Reis Fonseca, Luciana Araújo dos Reis   +6 more
doaj   +1 more source

Physical inactivity before stroke is associated with dependency in basic activities of daily living 3 months after stroke. [PDF]

Front Neurol, 2023
Susts J, Reinholdsson M, Sunnerhagen KS, Abzhandadze T.   +3 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Functional Status and Comorbidities in Older Patient Attending Outpatient in a Tertiary Care Hospital: An Observational Study

Journal of Nepal Medical Association
Introduction: With the increasing geriatric population, the demand of the geriatric care has been increasing worldwide. Numerous comorbidities like hypertension, COPD, diabetes mellitus, arthritis, are seen commonly in the older population of Nepal ...
Ananta Aryal, Anil Aryal, Rhijuta Pokharel, Shrinkhala Timsina, Shirjan Gautam, Saurav Jha, Subash Pant   +6 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Effect of home-based interventions on basic activities of daily living for patients who had a stroke: a systematic review with meta-analysis. [PDF]

BMJ Open, 2022
Qin P, Cai C, Chen X, Wei X.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Dressing Oneself With Words: Key Points for Recovering Basic Activities of Daily Living in Patients With Severe Alzheimer's Disease. [PDF]

Gerontol Geriatr Med, 2021
Yokoi T, Ri K.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source