Results 61 to 70 of about 131,344 (233)

Reliability and validity of the Geriatric Self-Care Scale among Chinese older adults

Annals of Medicine
Background Although the Geriatric Self-Care Scale (GSS) has been widely used in community investigations in China, its reliability and validity have yet to be analyzed.Objectives This study aimed to examine the reliability and validity of the GSS in ...
Hongji Zeng, Weijia Zhao, Rui Wang, Xin’ao Wang, Pengchao Luo, Xuyang Zhang, Xi Zeng   +6 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Predictors of costs in dementia in a longitudinal perspective. [PDF]

PLoS ONE, 2013
OBJECTIVE: To analyse predictors of costs in dementia from a societal perspective in a longitudinal setting. METHOD: Healthcare resource use and costs were assessed retrospectively using a questionnaire in four waves at 6-month intervals in a sample of ...
Hanna Leicht, Hans-Helmut König, Nina Stuhldreher, Cadja Bachmann, Horst Bickel, Angela Fuchs, Kathrin Heser, Frank Jessen, Mirjam Köhler, Melanie Luppa, Edelgard Mösch, Michael Pentzek, Steffi Riedel-Heller, Martin Scherer, Jochen Werle, Siegfried Weyerer, Birgitt Wiese, Wolfgang Maier, AgeCoDe study group   +18 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Functional capacity and associated factors among longevous senior individuals living in community: a population study in Northeastern Brazil

Fisioterapia e Pesquisa, 2014
The objective of this study was to determine the prevalence of impaired functional capacity and the associated factors in longevous elderly individuals from a city in the countryside of Northeastern Brazil.
Thaís Alves Brito, Marcos Henrique Fernandes, Raildo da Silva Coqueiro, Cleber Souza de Jesus, Roberta Freitas   +4 more
doaj   +2 more sources

A Comparison and Cross-validation of Models to Predict Basic Activity of Daily Living Dependency in Older Adults [PDF]

Medical Care, 2012
A simple method of identifying elders at high risk for activity of daily living (ADL) dependence could facilitate essential research and implementation of cost-effective clinical care programs.We used a nationally representative sample of 9446 older adults free from ADL dependence in 2006 to develop simple models for predicting ADL dependence at 2008 ...
Daniel O, Clark, Timothy E, Stump, Wanzhu, Tu, Douglas K, Miller   +3 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The Effect of Medical Check-up and Basic Physical Activities Daily Living: Panel Study on among Indoesian Elderly 1993-2000

Makara Journal of Health Research, 2010
In the 21st Century, Indonesia becomes the fourth biggest ageing country in the World as reported by the Second World Assembly on Ageing (2002). The Indonesian Household Health Survey (2001) reported 88,9% of the elderly suffered from disability ...
Indang Trihandini
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source