Results 61 to 70 of about 1,013,154 (317)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Trip Report on the Appalachian Adult Basic Education Special Project

open access: yes, 1969
A rough draft of the trip report on the Appalachian Adult Basic Education Special Project submitted by Appalachian Adult Basic Education Demonstration Center circa ...
Appalachian Adult Basic Education Demonstration Center
core  

Strategies That Transform: Self-Regulation and Volitional Control as Keys to Academic Achievement

open access: yesSocial Sciences
In recent years, research has highlighted a concerning lack of commitment and motivation among students on a global scale, leading to persistently low levels of competence across various areas of study.
Abílio Lourenço   +2 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

The Identification and Comparison of Attitudes Toward Education by Adult Basic Education Students, Teachers, and Administrators

open access: yes, 1969
Final report on the Mississippi module of the Identification and Comparison of Attitudes Toward Education by Adult Basic Education Students, Teachers, and Administrators submitted in February of ...
Appalachian Adult Basic Education Demonstration Center
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Adult Basic Education Guidance and Counseling Workshop, June 22-26, 1970

open access: yes, 1970
Final report on the Adult Basic Education Guidance and Counseling Workshop conducted from June 22 to June 26, 1970 and submitted by Appalachian Adult Basic Education Demonstration Center at Morehead State ...
Appalachian Adult Basic Education Demonstration Center
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Ensuring a More Evidence-based Policy for Basic Education [PDF]

open access: yes
Can the Philippines achieve its goal on two key international commitments--the Millennium Development Goals (MDGs) on Education and the Education for All (EFA) Initiative--for the achievement of education for everyone?
Albert, Jose Ramon G.   +1 more
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

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