Results 101 to 110 of about 47,738 (276)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

THE INFLUENCE OF ABILITIES AND AGILITY ON JUMPING SKILL OF YOUNG FEMALE VOLEYBALL PLAYERS [PDF]

Sport Mont, 2007
Success in sport depends on various factors but fi rst of all on continuous training process which is taking place in most sports disciplines on a regular daily basis. Besides one takes into account skillful work and training process adapted to abilities,
Dragan Nejić
doaj  

ANALYSIS OF THE INFLUENCE OF THE LEVEL OF DEVELOPMENT OF GYMNASTS' MOTOR ABILITIES ON THE SUCCESS OF MASTERING BASIC SKILLS

, 2023
Abstract: The article addresses the issues of the influence of the motor abilities of gymnasts of training groups on technical readiness, which is assessed by the results of the implementation of programs in conditions of competitive activity and the ability to demonstrate the technique of competitive exercises.
openaire   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Level of pre-school children basic locomotive motor abilities and skills

, 2012
This bachelor work contains theoretical chapters about motor abilities and skills, chapters about motor tests and evolution of preschool child. In practical part there is deal with problem of influence of three kindergartens on motor evolution of ...
Homolková, Zuzana
core  

EFFECT OF TEACHING STYLES AND MOTOR ABILITY ON RESULTS LEARNING SEPAK TAKRAW BASIC TECHNIQUES

JIPES - JOURNAL OF INDONESIAN PHYSICAL EDUCATION AND SPORT, 2018
The purpose of this study to find the effectiveness of teaching styles to the basic learning techniques sepaktaraw seen from motor ability. The method used is experiment with 2x3 factorial treatment design. The population used as the target population is the students of Physical Education Health and Recreation Universitas Islam Riau Force 2015/2016 ...
Ahcmad Sofyan Hanif, Moch. Asmawi, Zulkifli Zulkifli   +2 more
openaire   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Motor abilities in autism: A review using a computational context

, 2013
Altered motor behaviour is commonly reported in Autism Spectrum Disorder, but the aetiology remains unclear. Here, we have taken a computational approach in order to break down motor control into different components and review the functioning of each ...
Hamilton, Antonia, Gowen, Emma
core   +1 more source

MOTOR STRUCTURE AND BASIC MOVEMENT COMPETENCES IN EARLY CHILD DEVELOPMENT

Annales Kinesiologiae, 2010
Motor development consists of dynamic and continuous development in motor behaviour and is reflected in motor competences (on the locomotive, manipulative and postural level) and motor abilities (coordination, strength, speed, balance, flexibility ...
Rado Pišot, Jurij Planinšec
doaj   +2 more sources