Results 81 to 90 of about 4,712,528 (307)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Food for Thought: Basic Needs and Persistent Educational Inequality [PDF]
This research demonstrates that human capital accumulation by the poor is only possible if a minimum level of health and well-being has been attained. When families do not have enough resources to invest in the satisfaction of basic needs and health care,
David Mayer-Foulkes, Oded Galor
core
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Needs, equality and justice. Building an egalitarian proposal on basic needs [PDF]
, 2011 Las necesidades han sido y continúan siendo un tema recurrente tanto en la filosofía del derecho como en la filosofía política, y en las ciencias sociales en general, aunque se han tratado la mayoría de las veces de manera inadecuada, de forma poco ...
Ribotta, Silvina
core +1 more source
On information-optimal scripting of actions [PDF]
, 2019 Best paper award.Animals and humans encounter many tasks which permit ritualized behaviours, essentially fixed action sequences or “scripts”, similar to options known from Reinforcement Learning, but proceeding without intermediate decisions.
Polani, Daniel, Riegler, Bente
core +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Distance education possibilities analysis for integrated innovative projects [PDF]
, 2018 The materials presented the possibilities development of solar and wind power plants, project development for all those who are engaged in the power studies and baseness.
Aheicheva, Oleksandra +3 more
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
ReligionsModern Western societies are “aging” at a very high rate, and more and more people require assistance and care. Old age has different faces, which is due to genetic conditions, as well as the different contexts and lifestyles of people.
Ewa Gurba +2 more
doaj +1 more source
Basic Needs, Government Debt and Economic Growth [PDF]
This paper investigates the relationships between basic needs and economic growth where the interactions between output, health, nutrition and education are explicitly simultaneous.
Don Webber, Samuel Perlo-Freeman
core