Results 131 to 140 of about 359,364 (258)

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

Advanced Science, EarlyView.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin   +12 more
wiley   +1 more source

Restricted Network Reconstruction from Time Series via Dempster-Shafer Evidence Theory. [PDF]

Entropy (Basel)
Zhang C, Xian Y, Yuan X, Li M, Zhang Q.
europepmc   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

A Comparison of Algorithms to Achieve the Maximum Entropy in the Theory of Evidence. [PDF]

Entropy (Basel)
Abellán J, López-Gay A, Benítez MIA, Castellano FJG.   +3 more
europepmc   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Participation in a 20-Year Randomized Dietary Trial and University Enrollment. [PDF]

Health Sci Rep
Viinikainen J, Heineck G, Böckerman P, Pahkala K, Jula A, Kari JT, Lagström H, Niinikoski H, Pehkonen J, Rovio SP, Rönnemaa T, Salo P, Viikari J, Raitakari O.   +13 more
europepmc   +1 more source

Toward Flexible Printed Electronics: A Spider‐Silk‐Inspired, Strong and Tough Thermoplastic Polyamide Elastomer

Advanced Science, EarlyView.
Inspired by spider silk, a bio‐inspired polyamide elastomer with a dynamic physical cross‐linking network is developed. Mimicking the rigid β‐sheet crystals and sacrificial hydrogen bonds of silk, the material achieves an exceptional balance of strength and toughness.
Bo Yang, Liyue Zhang, Mengjing Yang, Hangzhi Guo, Zhibo Lin, Xinyu Qi, Wenjun Li, Haiyan Yan, Meng Li, Yanhui Chen, Weixing Chen, Zhenguo Liu, Wei Huang   +12 more
wiley   +1 more source

Genetic Assignment at Different Geographical Levels: A Case Study in a Forest Tree Species (<i>Pinus pinaster</i> Ait.) Using SNP Markers. [PDF]

Evol Appl
Olsson S, Grivet D, Westergren M, González-Martínez SC, Alía R, Robledo-Arnuncio JJ.   +5 more
europepmc   +1 more source

Chiral‐Encoded Pt‐Ir Surfaces as Apparent Spin Filter for Enhanced Oxygen Reduction

Advanced Science, EarlyView.
The Chiral‐Induced Spin Selectivity (CISS) effect is employed in chiral‐encoded mesoporous Platinum‐Iridium (Pt‐Ir) electrocatalysts to enhance the oxygen reduction reaction (ORR). A break in spin symmetry leads to a substantial antagonistic difference in activity (>200%) when comparing two enantiomorphs of the same electrode.
Zikkawas Pasom, Krissanapat Yomthong, Sopon Butcha, Jonas Fransson, Chularat Wattanakit, Alexander Kuhn   +5 more
wiley   +1 more source

Target trial emulation: bridging observational studies and randomized trials for health decision-making. [PDF]

J Comp Eff Res
Riggi E, Segelov E, Di Tanna GL.
europepmc   +1 more source