Results 121 to 130 of about 1,552,390 (331)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Mathematical model for the control of measles
Journal of Applied Sciences and Environmental Management, 2018 We proposed a mathematical model of measles disease dynamics with vaccination by considering the total number of recovered individuals either from natural recovery or recovery due to vaccination.
O.J. Peter +4 more
doaj +1 more source
A mathematical model for the novel coronavirus epidemic in Wuhan, China
Mathematical Biosciences and Engineering, 2020 We propose a mathematical model to investigate the current outbreak of the coronavirus disease 2019 (COVID-19) in Wuhan, China. Our model describes the multiple transmission pathways in the infection dynamics, and emphasizes the role of the environmental
Chayu Yang, Jin Wang
doaj +1 more source
The Basic Reproduction Number as a Predictor for Epidemic Outbreaks in Temporal Networks
PLOS ONE, 2015 The basic reproduction number R0 -- the number of individuals directly infected by an infectious person in an otherwise susceptible population -- is arguably the most widely used estimator of how severe an epidemic outbreak can be. This severity can be more directly measured as the fraction people infected once the outbreak is over, .
Holme, Petter, Masuda, Naoki
openaire +7 more sources
FEBS Open Bio, EarlyView.This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li +10 more
wiley +1 more source
Mathematical Biosciences and Engineering, 2007 Heterogeneity in sexual behavior is known to play an important role in the spread of HIV. In 1986, a mathematical model based on ordinary differential equations was introduced to take into account the distribution of sexual activity.
Nicolas Bacaër +3 more
doaj +1 more source
The basic reproduction number of SARS-CoV-2: a scoping review of available evidence
medRxiv, 2020 Background: The transmissibility of SARS-CoV-2 determines both the ability of the virus to invade a population and the strength of intervention that would be required to contain or eliminate the spread of infection.
Ann Barber +12 more
semanticscholar +1 more source
Basic Reproduction Numbers for a Class of Reaction-Diffusion Epidemic Models
Bulletin of Mathematical Biology, 2020 We study the basic reproduction numbers for a class of reaction-diffusion epidemic models that are developed from autonomous ODE systems. We present a general numerical framework to compute such basic reproduction numbers; meanwhile, the numerical formulation provides useful insight into their characterizations.
Yang, Chayu, Wang, Jin
openaire +3 more sources
SmallTalk: a novel small‐sized fusion tag for peptide expression and purification
FEBS Open Bio, EarlyView.The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq +3 more
wiley +1 more source
Epidemic threshold conditions for seasonally forced SEIR models
Mathematical Biosciences and Engineering, 2005 In this paper we derive threshold conditions for eradication of diseases that can be described by seasonally forced susceptible-exposed-infectious-recovered (SEIR) models or their variants. For autonomous models, the basic reproduction number $\mathcal{R}
Junling Ma, Zhien Ma
doaj +1 more source