Results 131 to 140 of about 1,511,149 (326)

Systematic evaluation of the population-level effects of alternative treatment strategies on the basic reproduction number

, 2018
An approach to estimate the influence of the treatment-type controls on the basic reproduction number, R 0 , is proposed and elaborated. The presented approach allows one to estimate the effect of a given treatment strategy or to compare a number of ...
Bulla, Ingo, Gromov, Dmitry, Romero-Severson, Ethan Obie   +2 more
core  

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

The role of asymptomatic carriers on the dynamics of a lymphatic filariasis model incorporating control strategies

Results in Control and Optimization
This study presents a mathematical model to investigate the patterns of transmission in lymphatic filariasis. The model considers chronic, acute, and asymptomatic individuals and integrates key control strategies.
Mussa A. Stephano, Maranya M. Mayengo, Jacob I. Irunde   +2 more
doaj   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

A Dynamical Analysis on a Tumour Virotherapy Model with Standard Incident Rate [PDF]

, 2017
This paper discusses a dynamical analysis on a model that governs the growth of tumour cell under a therapy by using oncolytic viruses, on the standard incident rate.
Ikawati, D. S. (Deasy), Kusumawinahyu, W. M. (Wuryansari), Trisilowati, T. (Trisilowati)   +2 more
core  

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Estimation of Basic Reproduction Number (Ro) of Novel Coronavirus (COVID-19) from SEIR Model in Perspective of Bangladesh

, 2020
Objective: The novel corona virus 19 (nCoV-19) created a global pandemic situation. To control this pandemic effectively, the basic reproduction number (Ro) is an effective epidemic tool.
T. Himel, Debnath Konad, R. Ahsan, Uddin Mohammod Misbah, Hussain Md. Safwan   +4 more
semanticscholar   +1 more source

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source

Global properties of an age-structured virus model with saturated antibody immune response, multi-target cells and general incidence rate

, 2017
Some viruses, such as human immunodeficiency virus, can infect several types of cell populations. The age of infection can also affect the dynamics of infected cells and production of viral particles.
Cervantes-Pérez, Ángel, Ávila-Vales, Eric   +1 more
core  

The basic reproduction number of vector-borne plant virus epidemics

Virus Research, 2017
The basic reproduction number R0 is a key parameter in plant disease epidemiology, which largely determines whether or not an epidemic will occur in a plant population. The next generation matrix approach to deriving and calculating the basic reproduction number of a plant virus epidemic is described.
Van den Bosch, F, Jeger, MJ
openaire   +5 more sources