Results 51 to 60 of about 24,995 (266)

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Long‐term prognosis is associated with residual disease after neoadjuvant systemic therapy but not with initial nodal status

BJS (British Journal of Surgery), EarlyView., 2020
This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund, F. Celebioglu, T. Hatschek, J. Frisell, J. de Boniface   +4 more
wiley   +1 more source

Modeling of Hydrocarbon Migration and Hydrocarbon-Phase State Behavior Evolution Process Simulation in Deep-Ultradeep Reservoirs of the Mo-Yong Area, Junggar Basin

Applied Sciences
To elucidate the mechanisms governing hydrocarbon accumulation and phase evolution in the deep–ultradeep reservoirs of the Mo-Yong area, this study integrated 2D basin modeling and multi-component phase state simulation techniques, investigating the ...
Bingbing Xu, Yuhong Lei, Likuan Zhang, Naigui Liu, Chao Li, Yan Li, Yuedi Jia, Jinduo Wang, Zhiping Zeng   +8 more
doaj   +1 more source

Oil and Gas Potential of Superimopsed Depressions in Azerbaijan

Горные науки и технологии, 2020
The Republic of Azerbaijan has significant potential in the oil and gas industry, which is the basic for the country economy. Prospects for the development of oil and gas production technologies are largely determined by the effectiveness of geological ...
A. A. Feizullaev, S. S. Kocharli, S. V. Abbasova   +2 more
doaj   +1 more source

Modeling Fluid Flow in Faulted Basins

Oil & Gas Science and Technology – Revue d’IFP Energies nouvelles, 2014
This paper presents a basin simulator designed to better take faults into account, either as conduits or as barriers to fluid flow. It computes hydrocarbon generation, fluid flow and heat transfer on the 4D (space and time) geometry obtained by 3D volume restoration.
Faille I., Thibaut M., Cacas M.-C., Havé P., Willien F., Wolf S., Agelas L., Pegaz-Fiornet S.   +7 more
openaire   +3 more sources

A Genomic Catalog of Migratory Microbiomes from Wild Birds across China's Habitats

Advanced Science, EarlyView.
ABSTRACT Migratory birds play an important role in the spread of antimicrobial resistance (AMR); however, gaps in surveillance data from vital regions along migratory flyways across China limit the detection of emergent threats. Here, we assembled 340 metagenomes from 52 bird species covering 11 provincial administrative districts in China, presenting ...
Yanan Wang, Heqi Wu, Mengqi Qu, Chunge Zhang, Ziqian Xu, Yuhang Pei, Chaochao Zhao, Jiangtao Wang, Sufang Ma, Na Lyu, Xuebin Xu, Yuhai Bi, Baoli Zhu, George F. Gao   +13 more
wiley   +1 more source

Designing Cost‐Effective Carbon Payments to Induce Cellulosic Feedstock Production for Sustainable Aviation Fuel

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Perennial bioenergy crops, such as miscanthus and switchgrass, and crop residues have the potential to scale up sustainable aviation fuel (SAF) production and mitigate carbon emissions. However, high establishment costs, delayed returns, and risk–return profiles that diverge from those of conventional crops can hinder incentives to adopt ...
Fahd Majeed, Madhu Khanna, Ruiqing Miao
wiley   +1 more source

Transient Thermal Effects in Sedimentary Basins with Normal Faults and Magmatic Sill Intrusions—A Sensitivity Study

Geosciences, 2019
Magmatic intrusions affect the basin temperature in their vicinity. Faulting and physical properties of the basin may influence the magnitudes of their thermal effects and the potential source rock maturation.
Magnhild Sydnes, Willy Fjeldskaar, Ivar Grunnaleite, Ingrid Fjeldskaar Løtveit, Rolf Mjelde   +4 more
doaj   +1 more source

Data‐Guided Photocatalysis: Supervised Machine Learning in Water Splitting and CO2 Conversion

Advanced Intelligent Discovery, EarlyView.
This review highlights recent advances in supervised machine learning (ML) for photocatalysis, emphasizing methods to optimize photocatalyst properties and design materials for solar‐driven water splitting and CO2 reduction. Key applications, challenges, and future directions are discussed, offering a practical framework for integrating ML into the ...
Paul Rossener Regonia, Christian Mark Pelicano   +1 more
wiley   +1 more source