Results 181 to 190 of about 8,304,922 (298)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Gene signatures and immune correlations in Parkinson's disease Braak stages. [PDF]

Eur J Med Res
Sun RX, Guo Y.
europepmc   +1 more source

Graph clustering based on mixing time of random walks

, 2014
Konstantin Avrachenkov, Mahmoud El Chamie, Giovanni Neglia   +2 more
openalex   +2 more sources

An exploratory spatial data analysis-based investigation of the hot spots and variability ofOmmastrephes bartramiifishery resources in the Northwestern Pacific Ocean [PDF]

, 2014
冯永玖 FENG Yongjiu, 陈新军 Chen Xinjun, 杨铭霞 YANG Mingxia, 霍 丹 HUO Dan, 朱国平 ZHU Guoping   +4 more
openalex   +1 more source

Diversifying bases [PDF]

Nature Chemical Biology, 2018
openaire   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Automated Monte Carlo-based Quantification and Updating of Geological Uncertainty with Borehole Data (AutoBEL v1.0)

, 2019
Zhen Yin, Sebastien Strebelle, Jef Caers
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

The Role of AI-Generated Clinical Image Descriptions in Enhancing Teledermatology Diagnosis: A Cross-Sectional Exploratory Study. [PDF]

Diagnostics (Basel)
Shapiro J, Greenfield B, Cohen I, Dodiuk-Gad RP, Valdman-Grinshpoun Y, Freud T, Lyakhovitsky A, Khamaysi Z, Avitan-Hersh E.   +8 more
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source