Results 291 to 300 of about 34,952,696 (369)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

The Current Status of Frailty and Influencing Factors in Elderly Patients With Hip Fractures: A Meta-Analysis. [PDF]

Biomed Res Int
Shou K, Wu Z, Xi Z, Zhao L, Li C, Bao T, Lv J, Shi Y.   +7 more
europepmc   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

To be (virtual) or not to be: six ways to get a grip on choosing a delivery method for your educational program. [PDF]

Can Med Educ J
Lahouaoula I, Buckley H, Nathoo N.
europepmc   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Characterization of defective coffee beans and blends differentiation based on ¹H qNMR technique. [PDF]

Curr Res Food Sci
Hu GL, Quan CX, Dai HP, Qiu MH.
europepmc   +1 more source

Novel FEV₁/FVC-based Diagnosis and Severity Classification of Chronic Obstructive Pulmonary Disease: How about FEV₁ % Predicted Basing? [PDF]

Am J Respir Crit Care Med
Ogata H, Washio Y, Yoshida M.
europepmc   +1 more source

Knowledge, attitudes and practices towards yaws in endemic areas of Ghana, Cameroon and Côte d'Ivoire. [PDF]

PLoS Negl Trop Dis
Beiras CG, Kouadio AT, Handley BL, Arhinful D, Tchatchouang S, Houndji ASS, Nartey ET, Sarpong DO, Menguena G, Ndzomo P, Basing LA, Hugues KA, Amanor IB, Bakheit M, Landmann E, Awondo P, Müller C, Crucitti T, Borst N, Becherer L, Lüert S, Frischmann S, Sylla A, Kouamé-Sina MS, Harding-Esch EM, Knauf S, Mitjà O, Eyangoh S, Addo KK, Kakou SN, Marks M.   +30 more
europepmc   +1 more source

The Denver Call for Action. [PDF]

Anim Front
europepmc   +1 more source

Reducing blood culture contamination: an environmental imperative. [PDF]

Access Microbiol
Gregg S, Purcell N, Doyle M, Chan G.
europepmc   +1 more source