Results 41 to 50 of about 5,721 (292)

Exploring the free energy landscape: from dynamics to networks and back. [PDF]

open access: yesPLoS Computational Biology, 2009
Knowledge of the Free Energy Landscape topology is the essential key to understanding many biochemical processes. The determination of the conformers of a protein and their basins of attraction takes a central role for studying molecular isomerization ...
Diego Prada-Gracia   +3 more
doaj   +1 more source

Convergence Analysis and Dynamical Nature of an Efficient Iterative Method in Banach Spaces

open access: yesMathematics, 2021
We study the local convergence analysis of a fifth order method and its multi-step version in Banach spaces. The hypotheses used are based on the first Fréchet-derivative only. The new approach provides a computable radius of convergence, error bounds on
Deepak Kumar   +3 more
doaj   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

open access: yesAdvanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu   +8 more
wiley   +1 more source

Asset price dynamics in a financial market with fundamentalists and chartists

open access: yesDiscrete Dynamics in Nature and Society, 2001
In this paper we consider a model of the dynamics of speculative markets involving the interaction of fundamentalists and chartists. The dynamics of the model are driven by a two-dimensional map that in the space of the parameters displays regions of ...
Carl Chairella   +2 more
doaj   +1 more source

Tumor Microenvironment‐Responsive Nanoreactor Induces Disulfidptosis in Pancreatic Cancer via Metabolic Interference and Redox Catalysis

open access: yesAdvanced Science, EarlyView.
Schematic illustration of a tumor microenvironment‐responsive nanoreactor for imaging‐guided induction of disulfidptosis in pancreatic cancer via metabolic interference and redox catalysis. (A) Stepwise fabrication of Pht@HMnO2‐HA, including MnO2 growth on a SiO2 template, template removal to form hollow mesoporous MnO2, Pht loading, and subsequent ...
Rui Fu   +10 more
wiley   +1 more source

Basins of attraction in forced systems with time-varying dissipation

open access: yes, 2019
We consider dissipative periodically forced systems and investigate cases in which having information as to how the system behaves for constant dissipation may be used when dissipation varies in time before settling at a constant final value.
Gentile, G   +3 more
core   +2 more sources

A dynamical systems hypothesis of schizophrenia. [PDF]

open access: yesPLoS Computational Biology, 2007
We propose a top-down approach to the symptoms of schizophrenia based on a statistical dynamical framework. We show that a reduced depth in the basins of attraction of cortical attractor states destabilizes the activity at the network level due to the ...
Marco Loh, Edmund T Rolls, Gustavo Deco
doaj   +1 more source

Dynamic Cell Mapping Algorithm for Computing Basins of Attraction in Planar Filippov Systems [PDF]

open access: yes, 2017
Discontinuities are a common feature of physical models in engineering and biological systems, e.g. stick-slip due to friction, electrical relays or gene regulatory networks.
ERAZO ORDONEZ, CHRISTIAN CAMILO   +10 more
core   +1 more source

Fundamental Challenges, Physical Implementations, and Integration Strategies for Ising Machines in Large‐Scale Optimization Tasks

open access: yesAdvanced Electronic Materials, EarlyView.
Ising machines are emerging as specialized hardware solvers for computationally hard optimization problems. This review examines five major platforms—digital CMOS, analog CMOS, emerging devices, coherent optics, and quantum systems—highlighting physics‐rooted advantages and shared bottlenecks in scalability and connectivity.
Hyunjun Lee, Joon Pyo Kim, Sanghyeon Kim
wiley   +1 more source

Riddled Attraction Basin and Multistability in Three-Element-Based Memristive Circuit

open access: yesComplexity, 2020
By coupling a diode bridge-based second-order memristor and an active voltage-controlled memristor with a capacitor, a three-element-based memristive circuit is synthesized and its system model is then built.
Quan Xu   +6 more
doaj   +1 more source

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