Results 251 to 260 of about 7,221,182 (312)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Cut and Taste: Functional Morphology of the Feeding Apparatus of the Longhorn Tick Haemaphysalis longicornis (Arachnida: Ixodida). [PDF]

J Morphol
Chong KL, Casadei-Ferreira A, Richter A, Büsse S, Giribet G, Farrell BD, Economo EP.   +6 more
europepmc   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

A Tale of Two Principles-Towards a Relational Perspective on the Free Energy Principle. [PDF]

Entropy (Basel)
Guénin-Carlut A.
europepmc   +1 more source

Variational Polaron Theory for Ground States of Strongly Coupled Light-Matter and Electron-Phonon Systems. [PDF]

J Phys Chem Lett
Thanh Phuc N.
europepmc   +1 more source

Functional Approximation Methods for Differentially Private Distribution Estimation. [PDF]

IEEE Trans Inf Forensics Secur
Tao Y, Sarwate AD.
europepmc   +1 more source

Basis Science Focus Forum Supplement introduction. [PDF]

OTA Int
Haller J.
europepmc   +1 more source

Perpetual Futures for Stocks: The SpaceX Pre-IPO Market. [PDF]

Entropy (Basel)
Gupta A, Polson NG.
europepmc   +1 more source

Intermolecular Interactions of Large Systems: Boron Nitrides, Acenes, and Coronenes. [PDF]

J Phys Chem A
Fishman V, Martin JML, Boese AD.
europepmc   +1 more source

Pre-seeding diabatic anchors for reproducible direct-dynamics quantum photodissociation: an 8-state full-dimensional DD-vMCG study of CH₂OO.

Phys Chem Chem Phys
Ma K, Worth GA.
europepmc   +1 more source