Results 71 to 80 of about 434,084 (296)

New directional bat algorithm for continuous optimization problems [PDF]

Expert systems with applications, 2017
Bat algorithm (BA) is a recent optimization algorithm based on swarm intelligence and inspiration from the echolocation behavior of bats. One of the issues in the standard bat algorithm is the premature convergence that can occur due to the low ...
Asma Chakri, R. Khelif, Mohamed Benouaret, Xin-She Yang   +3 more
semanticscholar   +1 more source

A Natural Sweetener‐inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals

Advanced Science, EarlyView.
This study develops a natural sweetener, the psicose‐inducible transgene expression (PURE) system based on an Agrobacterium tumefaciens–derived transcriptional repressor PsiR. The PURE system is highly specific to psicose, being insensitive to other sugars and structurally similar molecules.
Longliang Qiao, Zhihao Wang, Shasha Tang, Yuan Fang, Guiling Yu, Xiaoting Qiu, Lingxue Niu, Tao Yan, Xingwan Liu, Xiaoding Ma, Deqiang Kong, Yang Zhou, Ningzi Guan, Jinzhong Tian, Meiyan Wang, Haifeng Ye, Fengfeng Cai   +16 more
wiley   +1 more source

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

Nature Medicine, 2015
The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome (MERS)-CoV underscores the threat of cross-species transmission events leading to outbreaks in humans. Here we examine the disease potential of
Vineet D. Menachery, B. Yount, K. Debbink, S. Agnihothram, Lisa E. Gralinski, Jessica A. Plante, Rachel L. Graham, Trevor D. Scobey, Xingyi Ge, Eric F. Donaldson, S. Randell, A. Lanzavecchia, W. Marasco, Zhènglì Shí, R. Baric   +14 more
semanticscholar   +1 more source

Chaos-enhanced synchronized bat optimizer

, 2020
In this paper, a chaos-enhanced bat algorithm is proposed to tackle the global optimization problems. Bat algorithm is a relatively new stochastic optimizer inspired by the echolocation behavior of bats in nature.
Helong Yu, Nannan Zhao, Pengjun Wang, Huiling Chen, Chengye Li   +4 more
semanticscholar   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

First Report on Association of Hyperuricemia with Type 2 Diabetes in a Vietnamese Population

International Journal of Endocrinology, 2019
Background. Uric acid is a powerful free-radical scavenger in humans, but hyperuricemia may induce insulin resistance and beta-cell dysfunction. The study aimed to evaluate the association between hyperuricemia and hyperglycemia, considering the ...
Tran Quang Binh, Pham Tran Phuong, Nguyen Thanh Chung, Bui Thi Nhung, Do Dinh Tung, Tran Quang Thuyen, Duong Tuan Linh, Bui Thi Thuy Nga, Nguyen Anh Ngoc, Le Danh Tuyen   +9 more
doaj   +1 more source

Serological Evidence of Bat SARS-Related Coronavirus Infection in Humans, China

Virologica Sinica, 2018
In our previous works, we have reported genetically diverse SARS-related coronaviruses (SARSr-CoV) in a single bat cave, Yunnan province, China, and suggested that some SARSr-CoVs may have high potential to infect humans without the necessity for an ...
Ning Wang, Shi-Yue Li, Xinglou Yang, Huimin Huang, Yuji Zhang, Hua Guo, Chuming Luo, Maureen Miller, Guang-jian Zhu, Aleksei A. Chmura, E. Hagan, Ji-hua Zhou, Yun-Zhi Zhang, Lin‐Fa Wang, P. Daszak, Zhènglì Shí   +15 more
semanticscholar   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Examination of the Gas-Vapour Phase of Cigarette Smoke. 2nd Report: The Determination of the Carbon Monoxide Content of the Gas Phase of Cigarette Smoke - Zur Untersuchung der Gas-Dampf-Phase des Cigarettenrauches: 2. Mitteilung: Zur Bestimmung des Stickstoffmonoxids (NO) aus der Gasphase des Cigarettenrauches

Contributions to Tobacco and Nicotine Research, 1968
The NO content of the gas-vapour phase of cigarette smoke is determined by a simple colourimetric procedure: NO is absorbed by a solution of FeSO4 in diluted H2SO4 up to an equilibrium with the formation of the addition compound Fe•NO•SO4.
Barkemeyer H., Seehofer F.
doaj   +1 more source

Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility

Advanced Science, EarlyView.
We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang, Zhong‐Yuan Yang, Shi Wang, Yan Ge, Lan Lin, Mia Madel Alfajaro, Renata B. Filler, Wan‐Yao Song, Ming‐Zhu Kong, Jin Wei   +9 more
wiley   +1 more source