Results 81 to 90 of about 802,447 (332)

Gabpα‐Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat

Advanced Science, EarlyView.
This study identifies the Gabpα–Pparγ complex as a key transcriptional regulator that couples glycolysis to lactate‐driven thermogenesis in brown adipose tissue by directly activating Eno1 transcription. ‌Competitive disruption of this interaction impairs lactate metabolism and thermogenic capacity.
Zhihan Wang, Huanyu Wang, Qianqian Kang, Ruping Pan, Rui He, Min Yang, Jiadai Liu, Xuemin Peng, Yuyu Xie, Hongyan Deng, Wenshe Wang, Zengzhe Zhu, Jing Ge, Yulian Liu, Ronghui Gao, Yaming Guo, Peng Yu, Limeng Pan, Danpei Li, Pema Maretich, Xiaoping Luo, Xuefeng Yu, Yong Chen   +22 more
wiley   +1 more source

Disentangling left and right-handed neutrino effects in $$B\rightarrow K^{(*)}\nu \nu $$ B → K ( ∗ ) ν ν

European Physical Journal C: Particles and Fields
The first observation of $$\mathcal {B}\left( B^+\rightarrow K^+\nu \nu \right) $$ B B + → K + ν ν by the Belle II experiment lies almost $$3\sigma $$ 3 σ away from the Standard Model expectation.
S. Rosauro-Alcaraz, L. P. S. Leal
doaj   +1 more source

Hearing Loss: From Basic to Clinical Science

Advanced Science, EarlyView.
Abstract Hearing loss (HL) affects over 1.5 billion people globally, with genetic factors accounting for ≈50% of congenital cases. Therefore, HL has become a global health issue, driving extensive research from basic science to clinical applications. This Special Collection includes a total of 31 papers, among which 9 are review papers, 21 are research
Renjie Chai, Hai Huang, Jing Zou
wiley   +1 more source

Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. [PDF]

, 2019
Thermogenesis in brown adipose tissue (BAT) declines with age; however, what regulates this process remains poorly understood. Here, we identify mitochondria lipoylation as a previously unappreciated molecular hallmark of aged BAT in mice.
Chang, Chih-Hsiang, Chang, Hsin-Yi, Ikeda, Kenji, Ishihama, Yasushi, Jun, Heejin, Kajimura, Shingo, Oguri, Yasuo, Tajima, Kazuki, Wu, Jun, Yoneshiro, Takeshi   +9 more
core  

GRB 050713A: High Energy Observations of the GRB Prompt and Afterglow Emission

, 2006
Swift discovered GRB 050713A and slewed promptly to begin observing with its narrow field instruments 72.6 seconds after the burst onset, while the prompt gamma-ray emission was still detectable in the BAT.
A. D. Falcone, A. P. Beardmore, A. Stamerra, Aptekar R. L., Barthelmy S., Burrows D. N., C. Pagani, D. C. Morris, D. N. Burrows, H. Krimm, J. Reeves, M. Garczarczyk, M. Gaug, M. Teshima, Mirzoyan R., N. Galante, N. Gehrels, O. Godet, Piro L., S. Golenetskii, S. Mizobuchi, V. Pal’shin   +21 more
core   +3 more sources

Predictors and immunological correlates of sublethal mercury exposure in vampire bats [PDF]

, 2017
Mercury (Hg) is a pervasive heavy metal that often enters the environment from anthropogenic sources such as gold mining and agriculture. Chronic exposure to Hg can impair immune function, reducing the ability of animals to resist or recover from ...
Altizer, Sonia, Becker, Daniel J., Bentz, Alexandra B., Chumchal, Matthew M., Czirják, Gábor Á., Platt, Steven G., Rainwater, Thomas R., Streicker, Daniel G.   +7 more
core   +1 more source

Transition Metal Compounds for Aqueous Ammonium‐Ion Batteries: Storage Mechanisms and Electrode Design

Advanced Science, EarlyView.
Aqueous ammonium‐ion batteries leverage hydrogen‐bond‐mediated NH4+ storage in tunable transition metal compounds. Despite progress in Mn‐, V‐, Mo‐, and W‐based compounds, 2D LDHs, and MXenes, challenges like structural instability and slow kinetics persist. Future advances require robust host design, mechanistic understanding via operando studies, and
Can Li, Ziyuan Lan, Hanghang Liu, Yunxuan Jiang, Lingfeng Zhu, Xiaoning Li, Bo‐Tian Liu   +6 more
wiley   +1 more source

Interferon Regulatory Factor 3-Mediated Signaling Limits Middle-East Respiratory Syndrome (MERS) Coronavirus Propagation in Cells from an Insectivorous Bat

Viruses, 2019
Insectivorous bats are speculated to be ancestral hosts of Middle-East respiratory syndrome (MERS) coronavirus (CoV). MERS-CoV causes disease in humans with thirty-five percent fatality, and has evolved proteins that counteract human antiviral responses.
Arinjay Banerjee, Darryl Falzarano, Noreen Rapin, Jocelyne Lew, Vikram Misra   +4 more
doaj   +1 more source

mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue [PDF]

, 2016
Activation of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) has been proposed as an anti-obesity treatment. Moreover, cold-induced glucose uptake could normalize blood glucose levels in insulin-resistant patients.
Albert V, Christoph Handschin, Fatima Bosch, Greco‐Perotto R, Hao Q, Kristoffer Svensson, Marco Colombi, Michael N Hall, Mitsugu Shimobayashi, Sergio Muñoz, Vallerand AL, Verena Albert, Veronica Jimenez   +12 more
core   +4 more sources

Safety of Sodium‐Ion Batteries: Evaluation and Perspective from Component Materials to Cells, Modules, and Packs

Advanced Energy Materials, EarlyView.
This review provides a bottom‐up evaluation of sodium‐ion battery safety, linking material degradation mechanisms, cell engineering parameters, and module/pack assembly. It emphasizes that understanding intrinsic material stability and establishing coordinated engineering control across hierarchical levels are vital for preventing degradation coupling ...
Won‐Gwang Lim, Seoa Kim, Erik A. Wu, Darren H. S. Tan, Shawn Peng, Xiaolin Li   +5 more
wiley   +1 more source