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Continuous Manufacturing of Recombinant Drugs: Comprehensive Analysis of Cost Reduction Strategies, Regulatory Pathways, and Global Implementation [PDF]

Pharmaceuticals
The biopharmaceutical industry is undergoing a fundamental transformation from traditional batch manufacturing to continuous manufacturing (CM) for recombinant drugs and biosimilars, driven by regulatory support through the International Council for ...
Sarfaraz K. Niazi
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Integrated Continuous Wet Granulation and Drying: Process Evaluation and Comparison with Batch Processing

Pharmaceutics, 2023
The pharmaceutical industry is in the midst of a transition from traditional batch processes to continuous manufacturing. However, the challenges in making this transition vary depending on the selected manufacturing process.
Seth P. Forster, Erin Dippold, Abbe Haser, Daniel Emanuele, Robin Meier   +4 more
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Sustainability case studies on the use of continuous manufacturing in pharmaceutical production

Current Research in Green and Sustainable Chemistry, 2022
Continuous processing is now commonly used in the manufacturing of fine chemicals including agrochemicals and pharmaceuticals. Datasets are now available, including some on environmental sustainability aspects, that enable more direct comparison between ...
Mark S. Kerr, Kevin P. Cole
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Oscillatory flow chemical reactors [PDF]

Hemijska Industrija, 2014
Global market competition, increase in energy and other production costs, demands for high quality products and reduction of waste are forcing pharmaceutical, fine chemicals and biochemical industries, to search for radical solutions. One of the
Slavnić Danijela S., Bugarski Branko M., Nikačević Nikola M.   +2 more
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Heterotrophic Cultivation of Euglena gracilis in Stirred Tank Bioreactor: A Promising Bioprocess for Sustainable Paramylon Production

Molecules, 2022
Paramylon is a valuable intracellular product of the microalgae Euglena gracilis, and it can accumulate in Euglena cells according to the cultivation conditions.
Franjo Ivušić, Tonči Rezić, Božidar Šantek   +2 more
doaj   +1 more source

Hydrothermal liquefaction of biomass: Developments from batch to continuous process [PDF]

Bioresource Technology, 2015
This review describes the recent results in hydrothermal liquefaction (HTL) of biomass in continuous-flow processing systems. Although much has been published about batch reactor tests of biomass HTL, there is only limited information yet available on continuous-flow tests, which can provide a more reasonable basis for process design and scale-up for ...
Elliott, DC, Biller, P, Ross, AB, Schmidt, AJ, Jones, SB   +4 more
openaire   +3 more sources

Development and characterization of a continuous ultrasound emulsification and nano-emulsion polymerization process

Tetrahedron Green Chem, 2023
Typically, nano-emulsions are prepared in batch high-speed homogenization or ultrasound processes and polymerized afterwards in batch reactors. However, fully continuous processes have the potential to decrease production costs and energy consumption ...
Jonas Loncke, Arne Vancleef, Wim Dermaut, Leen Braeken, Leen C.J. Thomassen   +4 more
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Lubricant Sensitivity of Direct Compression Grades of Lactose in Continuous and Batch Tableting Process

Pharmaceutics, 2023
Modern pharmaceutical manufacturing based on Quality by Design and digitalisation is revolutionising the pharmaceutical industry. Continuous processes are promoted as they increase efficiency and improve quality control.
Gerald A. Hebbink, Pauline H. M. Janssen, Jurjen H. Kok, Lorenzo Menarini, Federica Giatti, Caterina Funaro, Salvatore Fabrizio Consoli, Bastiaan H. J. Dickhoff   +7 more
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Techno-Economic Evaluation and Optimization of Batch, Fed-Batch and Multistage Continuous Crystallization Processes

Chemistry Proceedings, 2022
Over the last decade, continuous manufacturing techniques have been increasingly used in the pharmaceutical manufacturing industry. However, despite the outstanding performance associated with the steady-state operation, continuous processes face common ...
Jiaxu Liu, Brahim Benyahia
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Batch Reverse Osmosis Desalination Modeling under a Time-Dependent Pressure Profile

Membranes, 2021
As world demand for clean water increases, reverse osmosis (RO) desalination has emerged as an attractive solution. Continuous RO is the most used desalination technology today.
Abdeljalil Chougradi, François Zaviska, Ahmed Abed, Jérôme Harmand, Jamal-Eddine Jellal, Marc Heran   +5 more
doaj   +1 more source