Results 71 to 80 of about 2,112 (259)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Politics of memory: Historical battlefields and sense of place
Nordia Geographical Publications, 2015 The historical landscapes of war and conflict — such as battlefields, remains of military constructions, memorials and graveyards — are fundamental parts of the national iconography of modern states.
Petri J. Raivo
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Parasite-enhanced immunotherapy: transforming the “cold” tumors to “hot” battlefields
Cell Communication and SignalingImmunotherapy has emerged as a highly effective treatment for various tumors. However, the variable response rates associated with current immunotherapies often restrict their beneficial impact on a subset of patients. Therefore, more effective treatment
Yujun Xie +5 more
doaj +1 more source
Journalism and MediaInflaming public opinion about narcotics was the collective goal of anti-narcotics organizers who emerged from the battlefields of the war on alcohol. The most famous was Richmond P.
Stephen Siff
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Polarization of public opinions on feminism in China
Humanities & Social Sciences CommunicationsGlobal efforts on feminism and women’s equality are undergoing intense challenges under the transformative impact of social media and artificial intelligence (AI).
Jinghua Piao +7 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Radical Housing JournalSince October 2023, we have witnessed the human and material devastation brought about by the horrific mediatised genocide of Palestinians in Gaza and the West Bank, itself preceded by a long history of ‘urbacide’—an intentional form of urban ...
Ana Vilenica +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source