Results 31 to 40 of about 2,089,555 (322)

Safety and efficacy of BAY 94‐9027, a prolonged‐half‐life factor VIII

Journal of Thrombosis and Haemostasis, 2017
Essentials Recombinant factor VIII BAY 94‐9027 conjugates in a site‐specific manner with polyethylene glycol. BAY 94‐9027 was given to patients with severe hemophilia A as prophylaxis and to treat bleeds. BAY 94‐9027 prevented bleeds at dose intervals up
M. Reding, Heng Joo Ng, L. Poulsen, M. Eyster, Ingrid Pabinger, H. J. Shin, R. Walsch, Michael M. Lederman, Maria Y. Wang, M. Hardtke, Lisa A. Michaels   +10 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The suppression of Antarctic bottom water formation by melting ice shelves in Prydz Bay

Nature Communications, 2016
A fourth production region for the globally important Antarctic bottom water has been attributed to dense shelf water formation in the Cape Darnley Polynya, adjoining Prydz Bay in East Antarctica.
G. D. Williams, L. Herraiz‐Borreguero, F. Roquet, T. Tamura, K. Ohshima, Y. Fukamachi, A. Fraser, L. Gao, H. Chen, C. McMahon, R. Harcourt, M. Hindell   +11 more
semanticscholar   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Chemical Profiling of Essential Oils from Main Culinary Plants—Bay (Laurus nobilis L.) and Rosemary (Rosmarinus officinalis L.) from Montenegro

Horticulturae
The aim of the research was to determine the yield, chemical composition and free radical-scavenging activity of the essential oils (EOs) in the leaves and fruit of wild-grown bay (Laurus nobilis L.) and rosemary(Rosmarinus officinalis L.)from the ...
Zoran S. Ilić, Ljiljana Stanojević, Lidija Milenković, Ljubomir Šunić, Aleksandra Milenković, Jelena Stanojević, Dragan Cvetković   +6 more
doaj   +1 more source

Biological characteristics of the catch from the 1986-87 Pacific herring, Clupea harengus pallasi, roe fishery in California [PDF]

, 1987
In Tomales Bay, 4-, 5-, and 6-yr-old herring, Clupea harengus pallasi, composed 85% by number of the 1986-87 season's catch. In San Francisco Bay, 2-, 3-, and 4-yr-old herring composed 88% of the roundhaul catch, and 4-, 5-, and 6-yr-old herring composed
Spratt, Jerome D.
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Sediment dynamics in adjacent bays of Fujian during late-spring spring tide

Frontiers in Marine Science
Bays are active land–sea transition zones where the internal hydrodynamic processes control the material exchange between the bay and open sea. Yet, the differences and potential connectivity of those processes between adjacent bays and off-bay areas ...
Meng Liu, Mengying Hu, Jun Ma, Bo Liu, Jian Gu, Bin Yu, Chuanqi Hu, Ruijia Jin, Yingtao Zhu   +8 more
doaj   +1 more source

Exploring Posturbanism in Annalee Newitz’s The Terraformers [PDF]

University of Bucharest Review. Literary and Cultural Studies Series
Annalee Newitz’s The Terraformers (2023) explores the endeavors of the Environmental Rescue Team (ERT), which consists of diverse humans, uplifted animals, engineered organisms, bots, drones, and AI, and how they strive to construct a sustainable planet,
Hatice Bay
doaj   +1 more source

Biomass estimates of Pacific herring, Clupea pallasi, in California from the 1990-91 spawning-ground surveys [PDF]

, 1991
The spawning biomass of Pacific herring, Clupea pallasi, estimated from spawning-ground surveys in San Francisco Bay declined to 45,850 tons this season, following a peak of 71,000 tons in the 1989-90 season. This is the first major decline since the
Spratt, Jerome D.
core