Results 141 to 150 of about 74,781 (265)

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Safety and Efficacy of Damoctocog Alfa Pegol in Previously Treated Children Aged 7 to < 12 Years With Severe Haemophilia A in the Phase 3, Open Label Alfa-PROTECT Main Study. [PDF]

Eur J Haematol
Ozelo MC, Luciani M, Glosli H, Kavakli K, Samji N, Makris GC, Tueckmantel C, Maas Enriquez M, Oliveira LC, Gupta S, Arbesú MG, Davoli M, Chan AKC, Mancuso ME.   +13 more
europepmc   +1 more source

Shadow‐Calibrated Stereo Vision for Colorimetric Sweat Analysis

Advanced Science, EarlyView.
By establishing a mathematical model that reconstructs 3D structures through geometric features of object shadows under controlled illumination, and combining it with Convolutional Neural Network‐based 2D image analysis for volumetric calibration, this work enables highly accurate 3D morphological reconstruction.
Ting Xiao, Yuwen Yan, Miaorong Lin, Jiahui Chen, Jianxin Meng, Xiang Cui, Peng Zhang, Fengyu Li   +7 more
wiley   +1 more source

From global guidelines for cardio-kidney-metabolic diseases management to national implementation: perspectives from the guideline workshop taskforce. [PDF]

Cardiovasc Diabetol
Wanner C, Cosentino F, Barnard-Kelly K, Battelino T, Blüher M, Boll HN, Brosius FC, Busetto L, Ceriello A, Gavin JR, Giorgino F, Green J, Ji L, Kellerer M, Koob S, Lalic N, Marx N, Nedungadi P, Parkin CG, Rodbard HW, Rydén L, Saboo B, Sheu WH, Standl E, Tacke F, Topsever P, Schnell O.   +26 more
europepmc   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

Lensless Quantitative Phase Imaging with Bayer-Filtered Color Sensors Under Sequential RGB-LED Illumination. [PDF]

J Imaging
Wu J, Li Y, Luo Y, Pan L, Song P, Xu Q.
europepmc   +1 more source

Cotton Recruits Soil‐Derived Delftia tsuruhatensis to Suppress Aphid Detoxification Via Salicylic Acid‐Mediated Defense

Advanced Science, EarlyView.
This study systematically reveals a complex interactive network involving plants, microbes, and insects, elucidating the ecological and molecular mechanisms by which cotton enhances its resistance to aphids through the active recruitment of the beneficial soil bacterium Delftia tsuruhatensis.
Hui Xue, Fengchao Diao, Qiqing Yu, Xiangzhen Zhu, Tingfang Zhong, Li Wang, Kaixin Zhang, Dongyang Li, Jichao Ji, Junyu Luo, Jinjie Cui, Xueke Gao   +11 more
wiley   +1 more source

Random Neural Networks for Rough Volatility. [PDF]

Appl Math Optim
Jacquier A, Žurič Ž.
europepmc   +1 more source

Prediction of Structural Stability of Layered Oxide Cathode Materials: Combination of Machine Learning and Ab Initio Thermodynamics

Advanced Energy Materials, EarlyView.
In this work, we developed a phase‐stability predictor by combining machine learning and ab initio thermodynamics approaches, and identified the key factors determining the favorable phase for a given composition. Specifically, a lower TM ionic potential, higher Na content, and higher mixing entropy favor the O3 phase.
Liang‐Ting Wu, Milica Zdravković, Dijana Milosavljević, Konstantin Köster, Olivier Guillon, Jyh‐Chiang Jiang, Payam Kaghazchi   +6 more
wiley   +1 more source

ESMO-ESTRO consensus statements on the safety of combining radiotherapy with EGFR, ALK, or BRAF/MEK inhibitors. [PDF]

ESMO Open
van Aken ESM, O'Cathail SM, Gandhi AK, Bussink J, Castelo-Branco L, Eriksen JG, Argilés G, Hiley CT, Atkinson V, Kaźmierska J, Calles A, Konopa K, Le Rhun E, McDonald F, Mountzios G, Putora PM, Muoio B, Ricardi U, Westphalen CB, Wrona A, Boot P, Pentheroudakis G, Belka C, Lordick F, Marijnen CAM, Martins-Branco D, De Ruysscher D, Barriuso J, Devnani B, de Jong MC, Prelaj A.   +30 more
europepmc   +1 more source