Results 161 to 170 of about 55,741 (307)
Advanced Science, EarlyView.Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li +13 more
wiley +1 more source
Shadow‐Calibrated Stereo Vision for Colorimetric Sweat Analysis
Advanced Science, EarlyView.By establishing a mathematical model that reconstructs 3D structures through geometric features of object shadows under controlled illumination, and combining it with Convolutional Neural Network‐based 2D image analysis for volumetric calibration, this work enables highly accurate 3D morphological reconstruction.
Ting Xiao +7 more
wiley +1 more source
Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound
Advanced Science, EarlyView.Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García +11 more
wiley +1 more source
Policy-related small.area estimation
A method of small-area estimation with a utility function is developed. The utility characterises a policy planned to be implemented in each area, based on the area?s estimate of a key quantity.
LONGFORD Nicholas Tibor
core
Bayes factor scoring of GMMs for speaker verification
, 2004 This paper implements and assesses the Bayes factor as a replacement verification criterion to the likelihood-ratio test in the context of GMM-based speaker verification.
Vogt, Robert J., Sridharan, Sridha
core
Advanced Science, EarlyView.This study systematically reveals a complex interactive network involving plants, microbes, and insects, elucidating the ecological and molecular mechanisms by which cotton enhances its resistance to aphids through the active recruitment of the beneficial soil bacterium Delftia tsuruhatensis.
Hui Xue +11 more
wiley +1 more source
Advanced Science, EarlyView.SpaMode introduces a versatile framework for spatial multi‐omics integration across vertical, horizontal, and mosaic scenarios. By disentangling modality‐invariant and variant features through a mixture‐of‐experts mechanism, it adaptively reconfigures spatially heterogeneous signals.
Xubin Zheng +6 more
wiley +1 more source
Bayes factor null hypothesis tests provide a viable alternative to frequentist measures of evidence quantification. Bayes factors for realistic interesting models cannot be calculated exactly, but have to be estimated, which involves approximations to ...
Schad, Daniel J., Vasishth, Shravan
core
Advanced Science, EarlyView.A high‐performance 3D scaffold integrating rGO and SHEDs is developed to overcome impaired healing in diabetic bone defects. By driving extracellular matrix remodeling, rGO creates a pro‐angiogenic niche that significantly accelerates in vitro vascular network formation.
Can Zhang +12 more
wiley +1 more source
Advanced Science, EarlyView.A self‐supervised multi‐view graph fusion framework integrates spatial multi‐omics, excelling in domain identification and denoising. It reconstructs spatial pseudo‐expression, jointly analyzes multi‐omics data, infers RNA velocity, predicts spatial omics features from single‐cell multi‐omics, and detects spatially dark genes and transcription factors,
Yuejing Lu +8 more
wiley +1 more source