Results 211 to 220 of about 2,617,552 (333)

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet, Anna Largajolli, Petra M. Jauslin, Emilie Schindler, Mourad Hamimed, Wannee Kantasiripitak, Antonio Gonçalves, Eline Van Maanen, Khaled Benkali, Tomohisa Saito, Jonathan I. Silverberg, Andreas Wollenberg, Michael Graeber, Liliana Ulianov, Christophe Piketty, Luca Loprete, Vincent Duval, Nathalie Wagner   +17 more
wiley   +1 more source

A novel extension of the exponential distribution with application in modeling complex lifetime and environmental data. [PDF]

Sci Rep
Aljohani HM, Zaghdoun FM, Meraou MA, Alharthi AS, Almohri WAJ, Kalantan ZI, El-Helbawy AA, Hussam E, Muse AH.   +8 more
europepmc   +1 more source

Mechanism‐informed machine learning for individualized tacrolimus dose adjustment in the early post‐kidney transplant period

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tacrolimus dosing in the early post‐kidney transplant period is challenging due to a narrow therapeutic index and substantial interindividual pharmacokinetic (PK) variability. This study aimed to develop and validate mechanism‐informed machine learning (ML) models to support individualized tacrolimus dosing during this critical period ...
Hui Yu, Zihan Qin, Logan S. Smith, Jeong M. Park, Hao‐Jie Zhu   +4 more
wiley   +1 more source

Uncertainty quantification enables reliable deep learning for protein-ligand binding affinity prediction. [PDF]

Sci Rep
Rayka M, Naghavi SS.
europepmc   +1 more source

Activism as education in and through the youth climate justice movement

British Educational Research Journal, EarlyView.
Abstract Young people worldwide are increasingly participating in a global movement for climate justice, yet to date, little research has examined how youth climate justice activists conceive of and experience activism as education. The present study used in‐depth, semi‐structured interviews with 16 US climate justice activists (aged 15–17) to address ...
Carlie D. Trott
wiley   +1 more source

On the robustness of Bayesian inference of gene flow to intragenic recombination and natural selection. [PDF]

Mol Biol Evol
Thawornwattana Y, Rannala B, Yang Z.
europepmc   +1 more source

Robust hierarchical Bayes estimation of small area characteristics in the presence of covariates and outliers

, 1995
G. S. Datta, P. Lahiri
semanticscholar   +1 more source

Hybrid Cramér-Rao Bound for Quantum Bayes Point Estimation with Nuisance Parameters. [PDF]

Entropy (Basel)
Zhang J, Suzuki J.
europepmc   +1 more source

A Guide to Bayesian Optimization in Bioprocess Engineering

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Bayesian optimization has become widely popular across various experimental sciences due to its favorable attributes: it can handle noisy data, perform well with relatively small data sets, and provide adaptive suggestions for sequential experimentation.
Maximilian Siska, Emma Pajak, Katrin Rosenthal, Antonio del Rio Chanona, Eric von Lieres, Laura M. Helleckes   +5 more
wiley   +1 more source

Integration of affective cues in context-rich and dynamic scenes varies across individuals. [PDF]

Nat Commun
Ortega J, Murai Y, Whitney D.
europepmc   +1 more source