Results 21 to 30 of about 69,629 (213)
Statistical parametric mapping of biomechanical one-dimensional data with Bayesian inference
International Biomechanics, 2019 Recent developments in Statistical Parametric Mapping (SPM) for continuum data (e.g. kinematic time series) have been adopted by the biomechanics research community with great interest. The Python/MATLAB package spm1d developed by T.
Ben Serrien +2 more
doaj +1 more source
Statistical Significance Testing for Mixed Priors: A Combined Bayesian and Frequentist Analysis
Entropy, 2022 In many hypothesis testing applications, we have mixed priors, with well-motivated informative priors for some parameters but not for others. The Bayesian methodology uses the Bayes factor and is helpful for the informative priors, as it incorporates ...
Jakob Robnik, Uroš Seljak
doaj +1 more source
Default Priors in a Zero-Inflated Poisson Distribution: Intrinsic Versus Integral Priors
MathematicsPrior elicitation is an important issue in both subjective and objective Bayesian frameworks, where prior distributions impose certain information on parameters before data are observed.
Junhyeok Hong, Kipum Kim, Seong W. Kim
doaj +1 more source
Bayes factors for detection of Quantitative Trait Loci
Genetics Selection Evolution, 2001 A fundamental issue in quantitative trait locus (QTL) mapping is to determine the plausibility of the presence of a QTL at a given genome location. Bayesian analysis offers an attractive way of testing alternative models (here, QTL vs.
Pérez-Enciso Miguel +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
BFpack: Flexible Bayes Factor Testing of Scientific Theories in R
Journal of Statistical Software, 2021 There have been considerable methodological developments of Bayes factors for hypothesis testing in the social and behavioral sciences, and related fields.
Joris Mulder +13 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Scientific Journal of Informatics, 2018 Expert system is computer programs that mimic the thought process and expert knowledge in solving a particular problem. Basically, an expert system has various methods to diagnose various kinds of diseases experienced by humans, animals, and plants. This
Khairina Eka Setyaputri +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source