Results 41 to 50 of about 125,648 (258)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

The Bayesian Expectation-Maximization-Maximization for the 3PLM

open access: yesFrontiers in Psychology, 2019
The current study proposes an alternative feasible Bayesian algorithm for the three-parameter logistic model (3PLM) from a mixture-modeling perspective, namely, the Bayesian Expectation-Maximization-Maximization (Bayesian EMM, or BEMM).
Shaoyang Guo   +2 more
doaj   +1 more source

Bayesian estimates of linkage disequilibrium [PDF]

open access: yesBMC Genetics, 2007
The maximum likelihood estimator of D'--a standard measure of linkage disequilibrium--is biased toward disequilibrium, and the bias is particularly evident in small samples and rare haplotypes.This paper proposes a Bayesian estimation of D' to address this problem.
Sebastiani, Paola, Abad-Grau, María M.
openaire   +5 more sources

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

HyPE: Online Hybrid Pseudo-Bayesian Estimation Method for S-ALOHA-Based Tactical FANETs

open access: yesIEEE Access
Significant challenges are involved in tactical flying ad-hoc network (FANET) missions because network environments are very dynamic. In addition, energy-efficient network operation is important in tactical FANETs owing to the limited capacity of the on ...
Jimin Jeon   +7 more
doaj   +1 more source

Relevance Vector Machines for Enhanced BER Probability in DMT-Based Systems

open access: yesJournal of Electrical and Computer Engineering, 2010
A new channel estimation method for discrete multitone (DMT) communication system based on sparse Bayesian learning relevance vector machine (RVM) method is presented.
Ashraf A. Tahat, Nikolaos P. Galatsanos
doaj   +1 more source

How few countries will do? Comparative survey analysis from a Bayesian perspective

open access: yesSurvey Research Methods, 2012
Meuleman and Billiet (2009) have carried out a simulation study aimed at the question how many countries are needed for accurate multilevel SEM estimation in comparative studies.
Joop J.C.M. Hox   +2 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

open access: yesAging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss   +12 more
wiley   +1 more source

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