Results 151 to 160 of about 43,440 (267)

Association of environmental and socioeconomic indicators with serious mental illness diagnoses identified from general practitioner practice data in England: A spatial Bayesian modelling study. [PDF]

PLoS Med, 2022
Cruz J, Li G, Aragon MJ, Coventry PA, Jacobs R, Prady SL, White PCL.   +6 more
europepmc   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

Bayesian modelling demonstrates clinically relevant heterogeneity in Tau PET patterns in Alzheimer's disease. [PDF]

Eur J Nucl Med Mol Imaging
Xia Y, Johnson K, Fakhri GE, Guehl NJ, van de Giessen E, Coomans EC, Pijnenburg YAL, Ossenkoppele R, Groot C.   +8 more
europepmc   +1 more source

Estimating the conditional probability of developing human papilloma virus related oropharyngeal cancer by combining machine learning and inverse Bayesian modelling. [PDF]

PLoS Comput Biol, 2021
Tewari P, Kashdan E, Walsh C, Martin CM, Parnell AC, O'Leary JJ.   +5 more
europepmc   +1 more source

Correcting Apparent Priming Bias Unveils Fertilizer Nitrogen‐Risk Archetypes of Surplus and Depletion Across Asian Rice Systems

Advanced Science, EarlyView.
Correcting the apparent priming effect resolves systematic biases in Asian rice fertilizer nitrogen accounting. Net soil retention drops below 7%, while 48% of fertilizer escapes, inflicting US$98.53 billion in annual reactive‐nitrogen damages. High‐resolution mapping uncovers N‐risk archetypes across 42% of the rice area, delivering a spatially ...
Xiuyun Liu, Siyuan Cai, Longlong Xia, Jagdish K. Ladha, Xiaoyuan Yan, Xu Zhao   +5 more
wiley   +1 more source

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

A Bayesian modelling framework for estimating tick-borne pathogen transmission dynamics at the host-tick interface. [PDF]

PLoS Comput Biol
Kim Y, Faivre B, Boulinier T, Sineau C, Galon C, Moutailler S, Bournez L, Métras R.   +7 more
europepmc   +1 more source

A Portable Soft Robotic Glove with Fully Functional Thumb Assistance for Complex Dexterous Fine Motor Skills

Advanced Science, EarlyView.
A portable, sensorized, and controlled dexterous thumb‐enhanced glove helps stroke survivors swipe phones, twist caps, and perform other tasks. It is based on a powerful continuously, segmented origami dual chamber actuator to achieve active thumb CMC and MCP joint assistance and passively extend the IP joint.
Disheng Xie, Zhen Wang, Zhongping Ye, Minghao Liu, Xiangqian Shi, Shuk Fan Tong, Jianbin Liu, Chuanbin Mao, Thomas W. Leung, Haitao Liu, Raymond Kai‐yu Tong   +10 more
wiley   +1 more source

Bayesian modelling of the fossil record enlightens the evolutionary history of Hemiptera. [PDF]

Proc Biol Sci
Boderau M, Fu Y, Jiang H, Guan S, Peng A, Nel A, Jouault C.   +6 more
europepmc   +1 more source

Bayesian modelling of high-throughput sequencing assays with malacoda. [PDF]

PLoS Comput Biol, 2020
Ghazi AR, Kong X, Chen ES, Edelstein LC, Shaw CA.   +4 more
europepmc   +1 more source