Results 231 to 240 of about 236,656 (279)

Rhythms in longitudinal thalamic recordings are linked to seizure risk

open access: yesEpilepsia, EarlyView.
Abstract Objective Seizure unpredictability remains a major clinical challenge for people with epilepsy. Previous works have shown that seizure risk is associated with circadian and multi‐day cycles in both brain and physiological signals. However, it remains unclear whether neural activity from deep brain structures such as the anterior nucleus of the
Xinbing Zhang   +5 more
wiley   +1 more source

Artificial intelligence for adaptive neuromodulation in drug‐resistant epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects nearly one third of people with epilepsy and is associated with substantial cognitive, psychiatric, and mortality burdens. For patients who are not candidates for resection or laser interstitial thermal therapy, neuromodulation therapies such as vagus nerve stimulation, deep brain stimulation, and ...
Amir Hossein Daraie   +10 more
wiley   +1 more source

An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition

open access: yesEpilepsia, EarlyView.
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha   +13 more
wiley   +1 more source

Neural mechanisms of flexible perceptual inference. [PDF]

open access: yesPLoS Comput Biol
Schwarcz J   +6 more
europepmc   +1 more source

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