Results 151 to 160 of about 668,823 (341)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Integrating Radiomics and Computational Pathology to Predict Early Recurrence of Pancreatic Ductal Adenocarcinoma and Uncover Its Biological Basis in Tumor Microenvironment

Advanced Science, EarlyView.
Accurate prediction of early recurrence in pancreatic ductal adenocarcinoma is vital for optimizing treatment. A novel, integrated radiomics‐pathology machine learning model successfully forecasts recurrence risks by analyzing preoperative CT images and computational pathology.
Sihang Cheng, Fuze Cong, Shenbo Zhang, Rui Lv, Wenjia Zhang, Xinyi Ke, Juncheng Wu, Zhonghe Zhao, Kui Zhao, Di Dong, Ruofan Zhang, Zhengyu Jin, Max Seidensticker, Zhiwei Wang, Huanwen Wu, Xianlin Han, Nan Hong, Huadan Xue   +17 more
wiley   +1 more source

Effect of New Structures at Headland of Crenulate-Shaped Bays on the Equilibrium Shape of Bays in Mokran Coasts

International Journal of Coastal and Offshore Engineering, 2019
Construction of a new coastal structure changes the stable shape of the shoreline. This issue generally leads to sedimentation and erosion around adjacent structures due to changes in Littoral Sediment Transport (LST). This mechanism is considerably more
Mohammad Arian, Hassan Akbari, Seyed Mojtaba Hoseini Chavoshi   +2 more
doaj  

Introgressed Variation in TaMYB7‐A1 Drives Graded Dormancy and Climate‐Adaptive Pre‐Harvest Sprouting Resistance in Wheat

Advanced Science, EarlyView.
TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang, Dongzhi Wang, Yafei Guo, Qi Zheng, Min Zhang, James Simmonds, Jian Hou, Xuemei Liu, Xuelei Lin, Xiaomin Bie, Xiansheng Zhang, Xiaohui Li, Yuan Chen, Xueyong Zhang, Cristobal Uauy, Fei Lu, Chengcai Chu, Zhixi Tian, Jun Xiao   +18 more
wiley   +1 more source

Projective geometries arising from Elekes-Szab\'o problems

, 2019
We generalise the Elekes-Szab\'o theorem to arbitrary arity and dimension and characterise the complex algebraic varieties without power saving. The characterisation involves certain algebraic subgroups of commutative algebraic groups endowed with an ...
Bays, Martin, Breuillard, Emmanuel
core  

Crystal Facet‐Polysaccharide Matching in CFS‐P Nanocrystals Drives Fungal Uptake, Vacuole Destruction, and Selective Antifungal Activity

Advanced Science, EarlyView.
Facet‐engineered PVP‐capped CuFeSe2 nanocrystals exhibit potent, selective antifungal activity by strongly binding cell‐wall mannan, enabling vacuolar entry and organelle disruption. High‐index facets show superior mannan affinity, validated by theoretical calculations and experiments. CFS‐P induces vacuolar cavitation, mitochondrial abnormalities, and
Zhaohui Wang, Xiaojin Deng, Xujuan Huang, Yuhang Pan, Yao Qin, Lu Zhang, Le Xu, Tianyi Qin, Deteng Zhang, Yi Ma, Yalong Wang   +10 more
wiley   +1 more source

Physical Implementation of Optical Material‐Based Neural Networks Processing Enabled by Long‐Persistent Luminescence

Advanced Science, EarlyView.
This study reports on the physical implementation of optical material‐based neural processing using long‐persistent luminescence as memory‐retention and nonlinear optical material. The system performs optical‐domain preprocessing with opto‐electronic interfaces for stimulus delivery and readout, enabling real‐time demonstrations including Pong gameplay
Sangwon Wi, Yunsang Lee
wiley   +1 more source

Surface Engineering on Transition Metal Dichalcogenides: In Situ Encapsulation of Metal–Organic Frameworks for Highly Humidity‐Resistant Gas Sensing at Room Temperature

Advanced Science, EarlyView.
2D UiO‐66‐NH2/MoS2 was fabricated via an aqueous synthesis method to in situ encapsulation of MoS2 with 2D UiO‐66‐NH2 MOF. The humidity‐resistant NO2 sensing of 2D UiO‐66‐NH2/MoS2 at room temperature was accordingly enhanced by MOF encapsulation layer, along with the selectivity and stability.
Junwei Zeng, Weicheng Jiao, You Wang, Ye Yuan, Xiaodong He, Yue Niu   +5 more
wiley   +1 more source

Framing and face in Internet exchanges: A socio-cognitive approach

Linguistik Online, 1998
Hillary Bays
doaj   +1 more source

Correction: Quality of life improvements associated with weight loss using a novel shape-shifting hydrogel capsule: RESET study results. [PDF]

Int J Obes (Lond)
Kushner RF, Ard JD, Wadden TA, O'Neil PM, Bays HE, Greenway FL, Jakicic JM, Wyatt HR, Kenan Y, Asaraf LC, Donna H Ryan.   +10 more
europepmc   +1 more source