Results 21 to 30 of about 12,785 (215)
Ten things to know about ten cardiovascular disease risk factors (“ASPC Top Ten – 2020”)
American Journal of Preventive Cardiology, 2020 Preventive cardiology involves understanding and managing multiple cardiovascular disease (CVD) risk factors. Given the rapid advancements in medical science, it may be challenging for the busy clinician to remain up-to-date on the multifaceted and ...
Harold Edward Bays
doaj +1 more source
IDENTIFICATION OF HIGH POTENTIAL BAYS FOR HABs OCCURRENCE IN PENINSULAR MALYSIA USING PALSAR REMOTE SENSING DATA [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2016 Increasing frequency, intensity, and geographic distribution of Harmful algal blooms (HABs) poses a serious threat to the coastal fish/shellfish aquaculture and fisheries in Malaysian bays.
A. B. Pour, M. Hashim
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Investigación & DesarrolloLast-mile logistics represents a major cost and environmental challenge in dense urban centers, particularly in emerging economies. In Bolivia, where over 92% of retail transactions occur through informal nanostores, urban freight operations to supply ...
Santiago Lima +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Seafloor geomorphology of western Antarctic Peninsula bays: a signature of ice flow behaviour [PDF]
The Cryosphere, 2018 Glacial geomorphology is used in Antarctica to reconstruct ice advance during the Last Glacial Maximum and subsequent retreat across the continental shelf.
Y. P. Munoz, J. S. Wellner
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Frontiers in Environmental Science, 2023 Deliberative methods to assess ecosystem services values formalize community members’ and stakeholders’ involvement in decision-making related to natural resources management.
Jennifer Lyon-Mackie +6 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source