Results 231 to 240 of about 232,551 (308)

BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress. [PDF]

Nat Commun
Varkaris A, Wang K, Nouri M, Kozlova N, Schmidt DR, Stavridi A, Arai S, Ambrosio N, Poluben L, Jimenez-Vacas JM, Westaby D, Carmichael J, Xie F, Figueiredo I, Buroni L, Neeb A, Gurel B, Chevalier N, Brown L, Voznesensky O, Chen SY, Russo JW, Yuan X, Juric D, Beltran H, De Bono JS, Vander Heiden MG, Einstein DJ, Muranen T, Corey E, Sharp A, Balk SP.   +31 more
europepmc   +1 more source

Phytoestrogen Signal Pathways and Estrogen Signaling in Ovarian Cancer: A Narrative Review

Phytotherapy Research, EarlyView.
Phytoestrogen signal pathways targeted in ovarian cancer. ABSTRACT Ovarian cancer (OC) is the second most common gynecological cancer and the leading cause of death from gynecological malignancies. Ovarian cancer mortality rate ranks fifth among cancer‐related deaths in Western societies.
Ozgur Kutuk, Ayse Kaplan
wiley   +1 more source

Cellular and molecular mechanisms of arenobufagin in cancer therapy: a systematic review. [PDF]

Discov Oncol
Wang SJ, Wang PX, Ding HL, Qi YY, Song YR, Mu XN.   +5 more
europepmc   +1 more source

Comprehensive Osteosarcoma Treatment with Multifunctional Composite Hydrogels Enabling Combined Photothermal Cancer Ablation and Osteoinductive Tissue Regeneration

Small Methods, EarlyView.
This study presents a comprehensive strategy for treating osteosarcoma and promoting bone tissue regeneration using a multifunctional composite hydrogel composed of mineralized fibers with polyphenols. Furthermore, the biomaterial effectively mitigates the degenerative microenvironment including oxidative stress that develops after tumor ablation. This
Hayeon Byun, Taeyeon Hwang, Hyoryong Lee, Yun‐Jung Choi, Dong‐Jae Kim, Eunji Park, Eunhyung Kim, Sukho Park, Heungsoo Shin   +8 more
wiley   +1 more source

Discovery of PZ671, a highly potent and <i>in vivo</i> active CRBN-recruiting Bcl-xL degrader. [PDF]

RSC Med Chem
Zhang P, Thummuri D, Hu W, Khan S, He Y, Zhang X, Pal P, Lv D, Zhou D, Zheng G.   +9 more
europepmc   +1 more source

Extracellular vesicles derived from silicate‐stimulated antler reserve mesenchymal cells alleviate kidney damage in diabetic nephropathy through inhibiting abnormal angiogenesis and apoptosis

VIEW, EarlyView.
A novel bioengineering platform was invented to harness simple silicate ions to command highly regenerative deer antler cells, transforming them into super‐factories that massively produce customized extracellular vesicles (Si‐RM‐EVs) rich in therapeutic miR‐148a‐3p, dwarfing natural EV output and payload.
Pengfei Hu, Zhaowenbin Zhang, Dongxu Wang, Xiuying Li, Jiping Li, Jinchi Ying, Tiantian Jiang, Chen Zhao, Jiang Chang, Chunyi Li   +9 more
wiley   +1 more source

Overexpression of the circadian gene Bmal1 regulates the Nrf2/HO-1 oxidative stress pathway to alleviate inflammation and apoptosis in PC12 cells following cerebral ischemia-reperfusion injury. [PDF]

Medicine (Baltimore)
Zeng F, Wang M, Li Z, Zhang Y.
europepmc   +1 more source

Mechanism of Ammonia‐Induced Brain Damage in Chinese Striped‐Necked Turtle (Mauremys sinensis)

Integrative Zoology, EarlyView.
High levels of ammonia disrupt the integrity of the brain barrier in Mauremys sinensis, leading to tissue edema. This, in turn, triggers a series of cascade reactions, including disturbances in neurotransmitter levels, particularly glutamate, which might further exacerbate the neurotoxic effects.
Yunjuan Xiao, Xin Niu, Xueting Jiao, Liangping Lin, Haitao Shi, Meiling Hong, Li Ding   +6 more
wiley   +1 more source

MiR-484 Regulates the IL-6/STAT3 Signaling Pathway by Down-Regulating KLF12 to Inhibit the Malignant Progression of Cervical Cancer. [PDF]

Int J Womens Health
Bao K, Zhang X, Bao L, Tao X, Zhang L, Wang D.   +5 more
europepmc   +1 more source

HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death

Cell Death and Differentiation, 2003
H. Yanagisawa, T. Miyashita, Y. Nakano, Daisuke Yamamoto   +3 more
semanticscholar   +1 more source