Results 261 to 270 of about 232,551 (308)

Optimized <i>Eleutherine bulbosa</i> Urb. bulb extract on the inhibition of 3D retinoblastoma spheroids cultured in type I murine collagen. [PDF]

Int J Ophthalmol
Kamarudin AA, Sayuti NH, Cheng MZSZ, Saad N, Azmi NH, Mohd Esa N.   +5 more
europepmc   +1 more source

Selinexor Reduces the Immunosuppression of Macrophages and Synergizes With CD19 CAR‐T Cells Against B‐Cell Lymphoma

Cancer Science, EarlyView.
In the tumor microenvironment, selinexor suppresses tumor cell growth and prevents macrophages from polarizing to M2 populations. The lower concentration of selinexor decreases CAR‐T cell exhaustion, enhances its cytotoxicity, and upregulates NGFR expression to prompt CAR‐T cell proliferation.
Wenjing Luo, Jia Xu, Chenggong Li, Lu Tang, Yingying Li, Xindi Wang, Zhuolin Wu, Yinqiang Zhang, Heng Mei, Yu Hu   +9 more
wiley   +1 more source

Structural insights into MPXV P1 protein and its orthologs reveal conformational dynamics and a conserved antiviral pocket. [PDF]

Emerg Microbes Infect
Ni X, Wang Y, Fan X, Yu J, Lei J.
europepmc   +1 more source

GPD1L‐Mediated Glycerophospholipid Metabolism Dysfunction in Women With Diminished Ovarian Reserve: Insights From Pseudotargeted Metabolomic Analysis of Follicular Fluid

Cell Proliferation, EarlyView.
Our study demonstrated the downregulation of GPD1L and its mediated glycerophospholipid metabolism dysfunction in patients with diminished ovarian reserve. Moreover, we verified that GPD1L knockdown leads to increased cell apoptosis and mitochondrial dysfunction of KGN cells, as well as impaired oocyte quality.
Jiaqi Wu, Xuehan Zhao, Ying Fang, Cong Wang, Yichang Tian, Wan Tu, Qiqian Wu, Long Yan, Xiaokui Yang   +8 more
wiley   +1 more source

JCMM Annual Review on Advances in Biotechnology for the Treatment of Haematological Malignancies: A Review of the Latest In-Patient Developments 2024-2025. [PDF]

J Cell Mol Med
Shahid AM, Vainchenker W, Constantinescu SN.   +2 more
europepmc   +1 more source

Utilising Human Myometrial and Uterine Fibroid Stem Cell‐Derived Three Dimentional Organoids as a Robust Model System for Understanding the Pathophysiology of Uterine Fibroids

Cell Proliferation, EarlyView.
Three‐dimensional stem cell‐derived organoid model can serve as a robust platform to study the underlying molecular mechanisms of UFs, UFs health disparity, environmental risk factors, besides offering invaluable insights for potential therapeutic interventions.
Mervat M. Omran, Somayeh Vafaei, Samar Alkhrait, Farzana Liakath Ali, Maria Victoria Bariani, Tao Bai, Winston E. Thompson, Qiwei Yang, Mohamed Ali, Ayman Al‐Hendy   +9 more
wiley   +1 more source

Hamayou () protein hydrolysate ameliorates depression by regulating the mitogen-activated protein kinase pathway. [PDF]

J Tradit Chin Med
Weijia LI, Jing LU, Chao MA, Mengmeng L, Ke P, Hongyan C, Zhe L, Guangfu L.   +7 more
europepmc   +1 more source

Inhibition of Alkbh5 Attenuates Lipopolysaccharide‐Induced Lung Injury by Promoting Ccl1 m6A and Treg Recruitment

Cell Proliferation, EarlyView.
In septic lung injury mice, Alkbh5 is highly expressed, promoting the demethylation of m6A on Ccl1 mRNA, thereby reducing the stability of Ccl1 mRNA and decreasing Ccl1 expression. This, in turn, leads to reduced recruitment of Tregs, further exacerbating the symptoms of septic lung injury.
Hongdou Ding, Xinnan Xu, Yaoyao Zhu, Xinyu Ling, Li Xu   +4 more
wiley   +1 more source

RAF1 promotes anlotinib resistance in non-small cell lung cancer by inhibiting apoptosis. [PDF]

J Cancer Res Clin Oncol
Wu S, Hu C, Hu P, He W, Hui K, Jiang X.
europepmc   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source