Results 131 to 140 of about 34,325,732 (253)

Inhibition of Antiapoptotic BCL-XL, BCL-2, and MCL-1 Proteins by Small Molecule Mimetics

, 2010
Informatics and computational design methods were used to create new molecules that could potentially bind antiapoptotic proteins, thus promoting death of cancer cells. Apoptosis is a cellular process that leads to the death of damaged cells.
G. Prisco, D.S. Dalafave
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Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Unintended target effect of anti-BCL-2 DNAi

, 2017
Abdul Shukkur Ebrahim,1 Mustapha Kandouz,2 Nada Emara,1 Amara B Sugalski,3 Leonard Lipovich,3 Ayad M Al-Katib1 1Lymphoma Research Laboratory, 2Department of Pathology, School of Medicine, 3Center for Molecular Medicine and Genetics, Wayne State ...
Ebrahim AS, Sugalski AB, Kandouz M, Al-Katib AM, Lipovich L, Emara N   +5 more
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Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

BCL-2 family isoforms in apoptosis and cancer

The BCl-2 family has long been identified for its role in apoptosis. Following the initial discovery of BCL-2 in the contextof B-cell lymphoma in the 1980s, a number of homologous proteins have since been identified.
Michelle W. Wong-Brown (10660741), Nikola Bowden (21136433), Chloe F. A. Warren (21314846)   +2 more
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Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Dynamic Switching of Apoptosis-Modulating Bim Heterodimers in Response to BH3 Mimetics in Xenograft Models of Hematologic Malignancies. [PDF]

Mol Cancer Ther
Govindharajulu JP, Fluss S, Hollingshead MG, Gillette W, Esposito D, Newton DL, Stockwin LH, Chen L, Jiwani S, Dougherty K, Andrews O, Johnson BC, Evrard YA, Parchment RE, Doroshow JH, Srivastava AK.   +15 more
europepmc   +1 more source

Kelidonin hatása a Bcl-2 antiapoptotikus fehérje expressziójára humán uveális melanóma sejtvonalakon

, 2015
Itt bemutatott kísérleteinkben a benzofenantridinvázas alkaloidok családjába tartozó kelidonin hatását vizsgáltuk a Bcl-2 antiapoptotikus fehérje expressziós szintjére OCM-1 és OCM-3 humán uveális melanóma sejtvonalakon.
Szabó, Ágnes
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