Results 201 to 210 of about 34,325,732 (253)

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

A pore is a pore is a pore (or a hub?): VDAC oligomerization in mitochondrial connectivity and modulation. [PDF]

Biochem Soc Trans
De Pinto V, Battiato G, Conti-Nibali S, Cubisino SAM.   +3 more
europepmc   +1 more source

Decoding Molecular Mechanisms of Pongamia pinnata Phytochemicals in Cancer Therapy

Medicine Advances, EarlyView.
Pongamia pinnata phytochemicals have multiple anticancer mechanisms, including antioxidant, anti‐inflammatory, anti‐metastatic, and apoptosis‐inducing activities through molecular‐level regulation. These bioactive compounds protect normal cells from oxidative stress while promoting reactive oxygen species‐mediated tumor cell death and suppressing ...
Rajib Dhar, Vetriselvan Subramaniyan
wiley   +1 more source

Helminth-derived stefin-1 selectively reduces leukemic cell viability and promotes apoptosis in U937 cells. [PDF]

PLoS One
Ploensil P, Suwanwong Y, Phannasil P, Tarasuk M, Thonsri U, Prapasitsin P, Martviset P, Chantree P.   +7 more
europepmc   +1 more source

A Voxel‐Wise T2 Distribution Framework for Lesion Severity Stratification and Treatment‐Response Assessment in Stroke: Insights Into Suberoylanilide Hydroxamic Acid‐Induced Neuroprotection

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To evaluate lesion severity distribution in ischaemic brain lesions in spontaneously hypertensive rats (SHR) subjected to 90‐min transient middle cerebral artery occlusion (tMCAO), and to determine whether epigenetically based neuroprotection modifies lesion severity profiles using a voxel‐wise T2 distribution framework.
Andrea Díaz‐Pérez, Clara Penas, Francesc Jiménez‐Altayó, Silvia Lope‐Piedrafita   +3 more
wiley   +1 more source

Precision Diagnostics in Age-Related Hearing Loss: Emerging Molecular Biomarkers for Early Detection and Targeted Prevention. [PDF]

Int J Gen Med
Xia Z, Lin C, Wu Y, Liu H, Wu L, Shen Z.
europepmc   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Venetoclax for elderly patients with acute myeloid leukaemia unfit for intensive chemotherapy: Prospects, resistance mechanisms and management strategies. [PDF]

Clin Transl Med
Zhang J, Liu J, Zhao M, Zhang X, Liu L, Li M, Cao C, Zhang R, Zhao M.   +8 more
europepmc   +1 more source

Primary BPH Stromal Cell Cultures Exhibit Heightened Androgen‐Responsiveness

The Prostate, EarlyView.
ABSTRACT Background Benign prostatic hyperplasia (BPH) is the most common disease in aging males. BPH growth is androgen‐dependent, and it appears that androgens preferentially stimulate the growth of BPH as compared to normal prostate. The mechanism of preferential androgen stimulation of BPH growth is not clear.
Wei Chen, Fulu Dong, Mohammad Reza Askarpour, Laura E. Pascal, Rajiv Dhir, Uma Chandran, Bruce L. Jacobs, Donald B. DeFranco, Naoki Yoshimura, Zhou Wang   +9 more
wiley   +1 more source