Results 61 to 70 of about 1,954 (193)

CYTOTOXIC ACTIVITY OF Anredera cordifolia LEAF EXTRACT ON HELA CELLS

open access: yesBiotropia: The Southeast Asian Journal of Tropical Biology, 2018
Cervical cancer is the second most frequently occurring cancer among females all over the world. Since the best strategy against cancer is to kill the cancer cells without endangering the normal cells, discovering a potentially selective anticancer ...
Dita Maria Virginia   +2 more
doaj   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

open access: yesAdvanced Functional Materials, Volume 36, Issue 11, 5 February 2026.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen   +30 more
wiley   +1 more source

Dynamic expression of lamin B1 during adult neurogenesis in the vertebrate brain

open access: yesDevelopmental Dynamics, Volume 255, Issue 2, Page 187-208, February 2026.
Abstract Background In mammals, specific brain regions such as the dentate gyrus (DG) of the hippocampus and the subventricular zone (SVZ) of the lateral ventricles harbor adult neural stem/progenitor cells (ANSPCs) that give rise to new neurons and contribute to structural and functional brain plasticity.
Diana Zhilina   +12 more
wiley   +1 more source

A bivalent protein r-PB, comprising PA and BclA immunodominant regions for comprehensive protection against Bacillus anthracis

open access: yesScientific Reports, 2018
Anthrax infection is primarily initiated by B. anthracis endospores that on entry into the host germinate to vegetative cells and cause severe bacteremia and toxaemia employing an array of host colonisation factors and the lethal tripartite toxin.
Saugata Majumder   +5 more
doaj   +1 more source

Development of a 21-miRNA Signature Associated With the Prognosis of Patients With Bladder Cancer

open access: yesFrontiers in Oncology, 2019
Objective: To develop a prognostic signature for patients with bladder cancer (BC).Methods: We identified differentially expressed miRNAs between normal bladder tissue and bladder cancer in the TCGA-BCLA dataset and evaluated prognostic values of these ...
Xiao-Hong Yin   +14 more
doaj   +1 more source

Epidemiology and Economic Burden of Sleep Disorders in Europe

open access: yesEuropean Journal of Neurology, Volume 33, Issue 2, February 2026.
We investigated the epidemiology and costs of five major sleep disorders in Europe using systematic literature reviews, data harmonization, and imputation. Estimated adult prevalence was 18% for OSA, 10% for insomnia, 3% for RLS, 0.03% for narcolepsy, and 0.009% for RBD. In 2019, OSA had the highest economic impact in high‐income Europe (€184 billion),
Claudio L. A. Bassetti   +14 more
wiley   +1 more source

BVGA-Net: Lightweight Network Coupling BiLoop Vector-Mixed Gradient Aggregation for Quayside Crane Driver State Detection Against Complex Cockpit Interference

open access: yesIEEE Access
Driver state detection in port quayside cranes faces challenges from complex cockpit backgrounds and lightweight deployment needs. We proposed a lightweight detection network BVGA-Net based on an improved receptive-field attention mechanism and multi ...
Yong Zhang   +9 more
doaj   +1 more source

BCLA Volunteer Feature: Nancy Hannum

open access: yes, 2010
A new feature for the BCLA Browser, featuring stories from volunteers who have made a difference in BC's Library ...
Hannum, Nancy, Wass (Editor), Adrienne
core  

Realizing the promise of ‘La Dolce Vita’ via chemical biology: glycan‐motif editing of sLeX for precision cancer therapeutics

open access: yesThe FEBS Journal, Volume 292, Issue 14, Page 3616-3628, July 2025.
Modification of the glycocalyx via ‘glycan editing’ is distinguishable from ‘glycan‐motif editing’. The former broadly remodels the glycocalyx, whereas the latter inhibits expression only of a specific oligosaccharide motif within the glycocalyx by selectively dampening the bioactivity of the key glycosyltransferase(s) programming the biosynthesis of ...
Barbara Richichi, Robert Sackstein
wiley   +1 more source

Daytime sleepiness and BMI exhibit gender and age differences in patients with central disorders of hypersomnolence

open access: yesJournal of Sleep Research, Volume 34, Issue 3, June 2025.
In a cohort of central disorders of hypersomnolence, specifically women with idiopathic hypersomnia showed a marked subjective daytime sleepiness peak in the early 30s, while the body mass index only started to rise at that age. Better understanding of the pathophysiology of these gender and age‐specific characteristics will support tailored ...
Laura Ferrazzini   +31 more
wiley   +1 more source

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