Results 141 to 150 of about 125,674 (260)

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome.

New England Journal of Medicine, 2001
B. Druker, C. Sawyers, H. Kantarjian, D. Resta, Sofia Fernandes Reese, J. Ford, R. Capdeville, M. Talpaz   +7 more
semanticscholar   +1 more source

In Vivo Eradication of Human BCR/ABL-Positive Leukemia Cells With an ABLKinase Inhibitor [PDF]

, 2017
BACKGROUND: The leukemia cells of approximately 95% of patients with chronic myeloid leukemia and 30%-50% of adult patients with acute lymphoblastic leukemia express the Bcr/Abl oncoprotein, which is the product of a fusion gene created by a chromosomal ...
Buchdunger, Elisabeth, Cleris, Loredana, Formelli, Franca, Gambacorti-Passerini, Carlo, Giardini, Roberto, le Coutre, Philipp, Marchesi, Edoardo, Mologni, Luca   +7 more
core  

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.

Angewandte Chemie, 2016
Ashton C Lai, M. Toure, D. Hellerschmied, J. Salami, S. Jaime-Figueroa, Eunhwa Ko, J. Hines, C. Crews   +7 more
semanticscholar   +1 more source

Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.

Cancer Cell, 2005
E. Weisberg, P. Manley, W. Breitenstein, J. Brüggen, S. Cowan-Jacob, A. Ray, B. Huntly, D. Fabbro, G. Fendrich, Elizabeth Hall-Meyers, Andrew L. Kung, Andrew L. Kung, J. Mestan, G. Daley, Linda L. Callahan, L. Catley, C. Cavazza, Azam Mohammed, D. Neuberg, R. Wright, D. Gilliland, J. Griffin   +21 more
semanticscholar   +1 more source

Chronic Myeloid Leukemia with Rare e1a3 BCR-ABL Transcript

Pakistan Journal of Medicine and Dentistry
Chronic myelogenous leukemia (CML) results from neoplastic transformation of a hematopoietic stem cell. It is cytogenetically characterized by the presence of Philadelphia chromosome which results from reciprocal translocation t(9;22) that juxtaposes ...
Najia Tabassum, Rubina Ghani, Mohammad Saboor, Moinuddin Moinuddin   +3 more
doaj  

Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation.

ACS Medicinal Chemistry Letters, 2017
K. Shimokawa, N. Shibata, Tomoya Sameshima, Naoki Miyamoto, O. Ujikawa, H. Nara, Nobumichi Ohoka, T. Hattori, N. Cho, M. Naito   +9 more
semanticscholar   +1 more source

Ph -/BCR-ABL- [PDF]

, 2020
openaire   +1 more source

BCR-ABL tyrosine kinase [PDF]

Science-Business eXchange, 2009
openaire   +3 more sources

GST-pi expression in BCR-ABL+ and BCR-ABL- cells from CML patients.

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, 2000
Our laboratory has been involved in the study of glutathione-sulfhydryl-transferase-pi (GST-pi) for several years. We have recently observed that during haematopoiesis in BMSC liquid cultures from CML patients who were candidates for transplant GST-pi was expressed in presumably malignant cells during different stages of cellular maturation. To confirm
A, Marché-Cova, M T, Salles-Manuel, M M, Santamaría-Torres, A A, Fernández-Ortiz, P, Sobrevilla-Calvo, R, Rivas-González, R, Méndez-Martínez, E, Velazco-Escobar   +7 more
openaire   +1 more source

Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells

Science Translational Medicine, 2016
B. Carter, P. Mak, H. Mu, Hong-sheng Zhou, D. Mak, W. Schober, J. Leverson, Bin Zhang, R. Bhatia, Xuelin Huang, J. Cortes, H. Kantarjian, M. Konopleva, M. Andreeff   +13 more
semanticscholar   +1 more source