Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
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Background. Most patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors achieve durable optimal responses. Loss of the achieved molecular response is observed in 15–30 % of patients.
D. V. Kustova+11 more
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Quantification of minimal residual disease in patients with e1a2 BCR-ABL-positive acute lymphoblastic leukemia using a real-time RT-PCR assay [PDF]
Hiromitsu Yokota+10 more
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Additional chromosomal abnormalities and variability of BCR breakpoints in Philadelphia chromosome/BCR‐ABL‐positive acute lymphoblastic leukemia in Taiwan [PDF]
Bor‐Sheng Ko+10 more
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Outcome of relapsed or refractory acute B-lymphoblastic leukemia patients and BCR-ABL-positive blast cell crisis of B-lymphoid lineage with extramedullary disease receiving inotuzumab ozogamicin. [PDF]
Kayser S+13 more
europepmc +1 more source
Resistance of bcr‐abl‐positive acute lymphoblastic leukemia to daunorubicin is not mediated by mdr1 Gene Expression [PDF]
Mamta Gupta, Anil Kumar, Sunil Dabadghao
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Is There an Entity of Chemically Induced BCR-ABL–Positive Chronic Myelogenous Leukemia?
Abstract Learning Objectives After completing this course, the reader will be able to: Distinguish the exogenous causes of acute and chronic myelogenous leukemia.Discuss the evidence establishing the exogenous causes of secondary leukemia.Describe the relationship of radiation and chemical exposure to
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Targeting HSPA8 to repress GPX4 and induce ferroptosis in BCR-ABL positive leukemia
BCR-ABL positive (BCR-ABL+) leukemia is driven by constitutive activation of tyrosine kinase activity, with tyrosine kinase inhibitors (TKIs) serving as the standard treatment. However, resistance to TKIs remains a significant clinical challenge. In this
Shuxin Zhong+12 more
doaj
Evidence for a positive role of SHIP in the BCR-ABL–mediated transformation of primitive murine hematopoietic cells and in human chronic myeloid leukemia [PDF]
Xiaoyan Jiang+8 more
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Multiple tests of association with biological annotation metadata
We propose a general and formal statistical framework for multiple tests of association between known fixed features of a genome and unknown parameters of the distribution of variable features of this genome in a population of interest.
Mark J. Van Der Laan+4 more
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