Results 261 to 270 of about 179,498 (360)

Differential Impact of Pharmacokinetic and Pharmacodynamic Variability on Response to Combination Therapy

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Interindividual variability (IIV) in drug response complicates both fixed‐dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particularly in combination therapy, where multiple interacting pathways influence outcomes. This study employed
Kuteesa R. Bisaso, Ronald Kadada Karyaburo, Jackson K. Mukonzo, Ene I. Ette   +3 more
wiley   +1 more source

Chronic myeloid leukemia in blast phase masquerading as T-lymphoblastic lymphoma with t(22;22) karyotype: a case report. [PDF]

Front Oncol
Liu Y, Hao Z, Bai J, Zhou W, Zhang H, Guan Z, Zhang L, Li L.   +7 more
europepmc   +1 more source

Clinical Associations of Osteoporosis in BCR::ABL1 Negative Myeloproliferative Neoplasms. [PDF]

Int J Endocrinol
Aydin MS, Dagdas S, Pepeler MS, Korkmaz G, Alper A, Açıkgöz E, Bektas TN, Pamukçuoğlu M, Ceran F, Ozet G.   +9 more
europepmc   +1 more source

Circulating Tumor Cells in Multiple Myeloma: From Peripheral Clues to Central Insights

American Journal of Hematology, Volume 101, Issue 7, Page 1575-1588, July 2026.
CTC offer a minimally invasive widow into systemic myeloma biology, overcoming the sampling bias of bone marrow biopsies. Their prognostic value at diagnosis, potential role in MRD monitoring, and ability to capture clonal evolution highlight them as actionable biomarkers for future precision medicine.
Benjamin Podvin, Bruno Paiva, Irene M. Ghobrial, Salomon Manier   +3 more
wiley   +1 more source

Prolonged Antibiotic Exposure During Gestation Increases the Severity of Perinatal Asphyxia as Measured by EEG Reactivity in Rodents. [PDF]

Neurol Int
Morozan VP, Stancu M, Ionescu MI, Catrina AM, Mocanu A, Suhăianu V, Iacovache AV, Chirilă AT, Bordeianu A, Zăgrean L, Zăgrean AM, Moldovan M.   +11 more
europepmc   +1 more source

Immune, molecular and genetic profiles of gastric signet ring cell carcinoma: Recent progress and future challenges

International Journal of Cancer, Volume 159, Issue 1, Page 11-29, 1 July 2026.
Abstract Gastric signet ring cell carcinoma (GSRCC) is a special type of gastric cancer common in young women. Diffuse gastric cancer (DGC) begins with intramucosal lesions comprising differentiated GSRCC cells. Genetically, GSRCC and DGC are clonally identical, with their morphology influenced by extracellular Wnt signaling.
Qian Wang, Shuai Zhou, Xiongchao Fang, Xianli He, Gang Wang, Nan Wang   +5 more
wiley   +1 more source

AI-Driven BCR Modeling for Precision Immunology. [PDF]

Int J Mol Sci
Liu T, Zhao X, Yang F.
europepmc   +1 more source

Impact of Genomic Mutations on the Transcriptional Pathways and Tumor Microenvironment Landscape of Localized Early Prostate Cancer

The Prostate, Volume 86, Issue 10, Page 1103-1114, July 2026.
ABSTRACT Background The management of intermediate‐risk early prostate cancer (PCa) is challenging due to the difficulty in distinguishing indolent from aggressive tumors. This study explores the association between genomic alterations and the tumor and its microenvironment (TME) and implications for disease progression. Methods We performed multi‐omic
William Lautert‐Dutra, Camila M. Melo, Luiz P. Chaves, Francisco C. Souza, Vida Talebian, Cheryl Crozier, Mary Anne Quintayo, Linda Liao, Dan Dion, Fabiano P. Saggioro, Felipe S. Avante, Rodolfo B. dos Reis, Jeremy A. Squire, Jane Bayani   +13 more
wiley   +1 more source

Development of a Highly Sensitive SPR Biosensor for BCR-ABL Gene Sequence Detection Using a Novel Gold Nanoparticle-Enhanced Sandwich Assay Format. [PDF]

Micromachines (Basel)
Sobolevskyi MS, Lopatynskyi AM, Samoylov AV, Dorozinsky GV, Lyapin OM, Khrystosenko RV, Chegel VI, Pyeshkova VM, Errachid A, Dzyadevych SV, Soldatkin OO.   +10 more
europepmc   +1 more source

BCR::ABL1-ПОДОБНЫЙ В-ОЛЛ ВЗРОСЛЫХ. ДИАГНОСТИКА МЕТОДАМИ FISH И ИФТ

Ершов А. А., Алимова Г. А., Шишигина Л. А., Никифорова К. А., Басхаева Г. А., Бидерман Б. В., Котова Е. С., Гальцева И. В., Судариков А. Б., Алешина О. А., Обухова Т. Н., Паровичникова Е. Н.   +11 more
openalex   +1 more source