Results 1 to 10 of about 70,807 (355)

Dynamic density functional study of a driven colloidal particle in polymer solutions

, 2003
The Dynamic Density Functional (DDF) theory and standard Brownian dynamics simulations (BDS) are used to study the drifting effects of a colloidal particle in a polymer solution, both for ideal and interacting polymers.
A. Lang, A.A. Louis, A.A. Louis, A.J. Archer, A.J. Archer, A.P. Philipse, C.N. Likos, D.G. Aarts, F. Penna, F. Penna, F.H. Stillinger, J. Dzubiella, J. Dzubiella, P. Tarazona, P. Wette, P.G. Bolhius, S. Asakura, U. Marini Bettolo Marconi, U. Marini Bettolo Marconi, W.C.K. Poon   +19 more
core   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Chemical abundances of stars with brown-dwarf companions

, 2014
It is well-known that stars with giant planets are on average more metal-rich than stars without giant planets, whereas stars with detected low-mass planets do not need to be metal-rich.
Hernández, J. I. González, Israelian, G., Sahlmann, J., Santos, N. C., Sánchez, D. Mata, Udry, S.   +5 more
core   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

The "Mysterious" Origin of Brown Dwarfs

, 2004
Hundreds of brown dwarfs (BDs) have been discovered in the last few years in stellar clusters and among field stars. BDs are almost as numerous as hydrogen burning stars and so a theory of star formation should also explain their origin.
Ake Nordlund, Baraffe I., Boldyrev S., Bonnor W., Bouvier J., Comeron F., D'Antona F., Jeans J., Larson R., Larson R., Larson R., McCrea W., Motte F., Paolo Padoan   +13 more
core   +5 more sources

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Mapping of Business Development Services in Indonesia [PDF]

, 2008
This research aims to identify the tipology of Business Development Services (BDS) in Indonesia, including their strength and weaknesses and factors affecting the strength and weaknesses, from the perspective of BDS actors and their clients.

core  

Likelihood-Based Inference for Discretely Observed Birth-Death-Shift Processes, with Applications to Evolution of Mobile Genetic Elements

, 2014
Continuous-time birth-death-shift (BDS) processes are frequently used in stochastic modeling, with many applications in ecology and epidemiology. In particular, such processes can model evolutionary dynamics of transposable elements - important genetic ...
Biémont, Catlin, Cattamanchi, Crawford, Crawford, Dempster, Doss, Gagneux, Golinelli, Henrici, Huber, Kato-Maeda, Keiding, Lange, McEvoy, Minin, Rosenberg, Schwarz, Tanaka, Van Embden   +19 more
core   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Radial velocities of population II binary stars. II [PDF]

Baltic Astron. 14 (2005) 511-525, 2006
Here we publish the second list of radial velocities for 91 Hipparcos stars, mostly high transverse velocity binaries without previous radial velocity measurements. The measurements of radial velocities are done with a CORAVEL-type radial velocity spectrometer with an accuracy better than 1 km/s.
arxiv