Results 121 to 130 of about 70,807 (355)

Brown dwarf formation by gravitational fragmentation of massive, extended protostellar discs

open access: yes, 2007
We suggest that low-mass hydrogen-burning stars like the Sun should sometimes form with massive extended discs; and we show, by means of radiation hydrodynamic simulations, that the outer parts of such discs (R>100 AU) are likely to fragment on a ...
Hubber, David   +2 more
core   +2 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Orbital effects of spatial variations of fundamental coupling constants

open access: yes, 2011
We deal with the effects induced on the orbit of a test particle revolving around a central body by putative spatial variations of fundamental coupling constants $\zeta$.
Battat   +33 more
core   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

open access: yesFEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang   +9 more
wiley   +1 more source

Metal-rich T-dwarfs in the Hyades cluster

open access: yes, 2008
We present the results of a search for brown dwarfs (BDs) and very low mass (VLM) stars in the 625 Myr-old, metal-rich ([Fe/H]=0.14) Hyades cluster. We performed a deep (I=23, z=22.5) photometric survey over 16 deg$^2$ around the cluster center.
Eric Stempels   +3 more
core   +2 more sources

Bi-dimensional scaling map (BDS-Map): an approach for building large genetic maps [PDF]

open access: bronze, 1997
Stephen Goldberg   +4 more
openalex   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

open access: yesFEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli   +15 more
wiley   +1 more source

Expression of Salivary HIF-1α Levels Among the Clinical Stages of Oral Submucous Fibrosis

open access: yesPakistan Journal of Medicine and Dentistry
Background: Oral Submucous Fibrosis (OSMF) is defined as severe submucosal fibrosis and decreased vascularity, resulting in a compromised blood supply leading to hypoxia of tissues. The key biomarker involved is Hypoxia Inducible Factor-1α (HIF-1α). The
Kanwal Iqbal
doaj   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

open access: yesFEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee   +5 more
wiley   +1 more source

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