Results 31 to 40 of about 72,789 (286)

Using binary statistics in Taurus-Auriga to distinguish between brown dwarf formation processes

, 2017
Whether BDs form as stars through gravitational collapse ("star-like") or BDs and some very low-mass stars constitute a separate population which form alongside stars comparable to the population of planets, e.g. through circumstellar disk ("peripheral")
Béjar, V. J. S., Kroupa, P., Lodieu, N., López, R. Rebolo, Manjavacas, M. E., Marks, M., Martín, E. L., Thies, I., Velasco, S.   +8 more
core   +1 more source

Synthesis and Pharmacological Evaluation of a Novel Peptide Based on Anemonia sulcata BDS-I Toxin as a New KV3.4 Inhibitor Exerting a Neuroprotective Effect Against Amyloid-β Peptide [PDF]

, 2019
There is increasing evidence that the fast-inactivating potassium current IA, encoded by KV3. 4 channels, plays an important role in Alzheimer's Disease (AD), since the neurotoxic β-amyloid peptide1-42 (Aβ1-42) increases the IA current triggering ...
Annunziato, Lucio, Ciccone, Roselia, Grieco, Paolo, Merlino, Francesco, Pannaccione, Anna, Piccialli, Ilaria   +5 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

BD-CATS [PDF]

Proceedings of the International Conference for High Performance Computing, Networking, Storage and Analysis, 2015
Modern cosmology and plasma physics codes are now capable of simulating trillions of particles on petascale systems. Each timestep output from such simulations is on the order of 10s of TBs. Summarizing and analyzing raw particle data is challenging, and scientists often focus on density structures, whether in the real 3D space, or a high-dimensional ...
Md. Mostofa Ali Patwary, Suren Byna, Nadathur Rajagopalan Satish, Narayanan Sundaram, Zarija Lukić, Vadim Roytershteyn, Michael J. Anderson, Yushu Yao, null Prabhat, Pradeep Dubey   +9 more
openaire   +1 more source

New Brown Dwarfs and an Updated Initial Mass Function in Taurus

, 2004
I have performed a search for young low-mass stars and brown dwarfs (BDs) in 2 regions encompassing a total area of 4 deg^2 in the Taurus star-forming region, discovering 15 new members of Taurus.
Baraffe I., Comeron F., K. L. Luhman, Kenyon S. J., Kroupa P., Monin J.-L.   +5 more
core   +1 more source

A bilayer Double Semion Model with Symmetry-Enriched Topological Order [PDF]

, 2016
We construct a new model of two-dimensional quantum spin systems that combines intrinsic topo- logical orders and a global symmetry called flavour symmetry.
Martin-Delgado, M. A., Ortiz, L.
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Evaluation of BDS/GPS Multi-Frequency RTK Positioning Performance under Different Baseline Lengths

Remote Sensing, 2022
The BeiDou Navigation Satellite System (BDS) is fully operational and provides positioning, navigation, and timing services to users worldwide. To comprehensively evaluate the BeiDou-3 Navigation Satellite System (BDS-3) global real-time kinematic (RTK ...
Ershen Wang, Wei Song, Yize Zhang, Xiaozhu Shi, Zhi Wang, Song Xu, Wansen Shu   +6 more
semanticscholar   +1 more source

Dynamic density functional study of a driven colloidal particle in polymer solutions

, 2003
The Dynamic Density Functional (DDF) theory and standard Brownian dynamics simulations (BDS) are used to study the drifting effects of a colloidal particle in a polymer solution, both for ideal and interacting polymers.
A. Lang, A.A. Louis, A.A. Louis, A.J. Archer, A.J. Archer, A.P. Philipse, C.N. Likos, D.G. Aarts, F. Penna, F. Penna, F.H. Stillinger, J. Dzubiella, J. Dzubiella, P. Tarazona, P. Wette, P.G. Bolhius, S. Asakura, U. Marini Bettolo Marconi, U. Marini Bettolo Marconi, W.C.K. Poon   +19 more
core   +1 more source