Results 31 to 40 of about 3,655 (195)

Einleitung: Die IHRA-Arbeitsdefinition und die Diskussion um Begriffe und Definitionen von Antisemitismus [PDF]

Conflict & Communication Online, 2022
Die „Arbeitsdefinition Antisemitismus“ der „International Holocaust Remembrance Alliance“ führt nicht nur zu wissenschaftlichen Kontroversen zwischen ihren Befürworter:innen und Kritiker:innen, sie spielt – zumindest indirekt - auch für die Förderung ...
Florian Weis
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Childhood Bezoars: A Case Series [PDF]

Journal of Clinical and Diagnostic Research, 2018
Bezoars are the rarest causes of upper abdominal masses and upper gastric outlet obstruction in children and are most commonly seen in females of adolescent age.
Kamal Nain Rattan, Rashmi Hooda, Shalu Ogha, Ahmad Khursheed, Aashima   +4 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Cephalometric Assessment of Skeletal and Dental Determinants ofAnterior Open Bite in Saudi Populations

Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College
Objective: To evaluate craniofacial and dental cephalometric characteristics associated with anterior open bite and compare them with individuals exhibiting normal occlusion among the Saudi population.
Muhammad Abdullah kamran, Huda Alnami , Meeral Alfahad , Montaha Alfathi , Reema Malwi   +4 more
doaj   +1 more source

BD-CATS [PDF]

Proceedings of the International Conference for High Performance Computing, Networking, Storage and Analysis, 2015
Modern cosmology and plasma physics codes are now capable of simulating trillions of particles on petascale systems. Each timestep output from such simulations is on the order of 10s of TBs. Summarizing and analyzing raw particle data is challenging, and scientists often focus on density structures, whether in the real 3D space, or a high-dimensional ...
Md. Mostofa Ali Patwary, Suren Byna, Nadathur Rajagopalan Satish, Narayanan Sundaram, Zarija Lukić, Vadim Roytershteyn, Michael J. Anderson, Yushu Yao, null Prabhat, Pradeep Dubey   +9 more
openaire   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Comparison of Pericapsular Nerve Group Block and Femoral Nerve Block for Ease of Positioning During Spinal Anaesthesia in Hip Fracture Surgeries: A Prospective Randomized Controlled Trial [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy
Background: Hip fractures often require spinal anaesthesia for surgery, but positioning for spinal anaesthesia is painful, necessitating preoperative regional nerve blocks. This study compares ultrasound-guided pericapsular nerve group (PENG) and femoral
Tarun Yadav, Mayuri Golhar, Himadri Chanda, Deepender Wason, Jatin Lal, Susheela Taxak   +5 more
doaj   +1 more source