Results 31 to 40 of about 77,848 (283)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Using binary statistics in Taurus-Auriga to distinguish between brown dwarf formation processes
, 2017 Whether BDs form as stars through gravitational collapse ("star-like") or BDs and some very low-mass stars constitute a separate population which form alongside stars comparable to the population of planets, e.g. through circumstellar disk ("peripheral")
Béjar, V. J. S. +8 more
core +1 more source
A bilayer Double Semion Model with Symmetry-Enriched Topological Order [PDF]
, 2016 We construct a new model of two-dimensional quantum spin systems that combines intrinsic topo- logical orders and a global symmetry called flavour symmetry.
Martin-Delgado, M. A., Ortiz, L.
core +3 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Evaluation of BDS-2 and BDS-3 Satellite Atomic Clock Products and Their Effects on Positioning
Remote Sensing, 2021 The BeiDou Navigation Satellite System (BDS) has completed third phase construction and currently provides global services, with a mixed constellation of BDS-2 and BDS-3. The newly launched BDS-3 satellites are equipped with rubidium and passive hydrogen
Shengfeng Gu +5 more
doaj +1 more source
Proto-Brown Dwarf Disks as Products of Protostellar Disk Encounters [PDF]
, 2006 The formation of brown dwarfs via encounters between proto-stars has been confirmed with high-resolution numerical simulations with a restricted treatment of the thermal conditions.
Bate M. R. +5 more
core +2 more sources
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Study on antimicrobial effect of disinfecting solutions on alginate impression materials
Update Dental College Journal, 2014 Oral cavity contains 600 species of microbes named oral flora.Dental impressions get contaminated with micro-organisms from patients blood or saliva. So, impressions are recommended to disinfect before their further working steps.
Mohamad Rafiul Ahsan +2 more
doaj +1 more source
New Brown Dwarfs and an Updated Initial Mass Function in Taurus
, 2004 I have performed a search for young low-mass stars and brown dwarfs (BDs) in 2 regions encompassing a total area of 4 deg^2 in the Taurus star-forming region, discovering 15 new members of Taurus.
Baraffe I. +5 more
core +1 more source