Results 41 to 50 of about 72,789 (286)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Advances in BeiDou Navigation Satellite System (BDS) and satellite navigation augmentation technologies

, 2020
Several noteworthy breakthroughs have been made with the BeiDou Navigation Satellite System (BDS) and other global navigation satellite systems as well as the associated augmentation systems, such as the commissioning of the BDS-3 preliminary system and ...
Rui Li, Shuaiyong Zheng, Ershen Wang, Jinping Chen, S. Feng, Dun Wang, L. Dai   +6 more
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

PPP models and performances from single- to quad-frequency BDS observations

, 2020
Nowadays, China BeiDou Navigation Satellite System (BDS) has been developed well and provided global services with highly precise positioning, navigation and timing (PNT) as well as unique short-message communication, particularly global system (BDS-3 ...
Shuanggen Jin, Ke Su
semanticscholar   +1 more source

Orbital effects of spatial variations of fundamental coupling constants

, 2011
We deal with the effects induced on the orbit of a test particle revolving around a central body by putative spatial variations of fundamental coupling constants $\zeta$.
Battat, Benz, Berengut, Bertotti, Calura, Calura, Casotto, Damour, Damour, Damour, Damour, Degnan, Fouchet, Grevesse, Iorio, Khan, Konopliv, Lewis, Lorenzo Iorio, Merkowitz, Murphy, Müller, Müller, Pitjeva, Turyshev, Urey, Urey, Uzan, Williams, Williams, Williams, Williams, Williams, Yoder   +33 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Chemical abundances of stars with brown-dwarf companions

, 2014
It is well-known that stars with giant planets are on average more metal-rich than stars without giant planets, whereas stars with detected low-mass planets do not need to be metal-rich.
Hernández, J. I. González, Israelian, G., Sahlmann, J., Santos, N. C., Sánchez, D. Mata, Udry, S.   +5 more
core   +1 more source

Proto-Brown Dwarf Disks as Products of Protostellar Disk Encounters [PDF]

, 2006
The formation of brown dwarfs via encounters between proto-stars has been confirmed with high-resolution numerical simulations with a restricted treatment of the thermal conditions.
Bate M. R., James Wadsley, Rice W., Sijing Shen, Watkins S. J., Watkins S. J.   +5 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

BD@IHA - La BD à la bibliothèque de l’IHA

Germano-Fil, 2022
En France, la bande dessinée est considérée comme le »neuvième art« et bénéficie d’un statut particulier. Il n’y a guère de librairie sans un large choix de BD pour tous les âges. En Allemagne, en revanche, les »Comics«, en particulier les mangas et les romans graphiques, ne se sont émancipés qu’au cours des vingt dernières années et sont sortis de ...
openaire   +2 more sources