Results 51 to 60 of about 3,655 (195)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Clinical decision-making algorithm for the management of Oroantral fistula: A comprehensive guide
Saudi Dental JournalOroantral fistula (OAF) is a persistent pathological communication between the oral cavity and the maxillary sinus, often arising as a complication of dental extractions, trauma, or surgical procedures involving the maxilla.
Fouad Alomari +8 more
doaj +1 more source
Algorithms, 2019 The characteristic of the satellite repeat shift time can reflect the status of the satellite operation, and is also one of the key factors of the sidereal filtering multipath correction.
Yanxi Yang, Jinguang Jiang, Mingkun Su
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Remote Sensing, 2019 Because of the special design of BeiDou navigation satellite system (BDS) constellation, the effects of ionospheric scintillation on operational BDS generally are more serious than on the global positioning system (GPS).
Xiaomin Luo +3 more
doaj +1 more source
Applied Mathematics-A Journal of Chinese UniversitiesIn this paper, we focus on the BDS test, which is a nonparametric test of independence. Specifically, the null hypothesis $H_{0}$ of it is that $\{u_{t}\}$ is i.i.d. (independent and identically distributed), where $\{u_{t}\}$ is a random sequence. The BDS test is widely used in economics and finance, but it has a weakness that cannot be ignored: over ...
Luo, Wen-ya +3 more
openaire +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
A Subset-Reduced Method for FDE ARAIM of Tightly-Coupled GNSS/INS
Sensors, 2019 The advanced receiver autonomous integrity monitoring (advanced RAIM, ARAIM) is the next generation of RAIM which is widely used in civil aviation. However, the current ARAIM needs to evaluate hundreds of subsets, which results in huge computational ...
Weichuan Pan +3 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source