Results 171 to 180 of about 999,841 (275)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

A High-Density Microchamber Array for the Analysis of Extracellular Vesicles Derived from Single Cells under Drug Treatment. [PDF]

Anal Chem
Stöcklin LR, Dietsche CL, Dittrich PS.
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

SUANPAN: scalable photonic linear vector machine. [PDF]

Light Sci Appl
Yang Z, Li C, Ran Y, Li Y, Feng X, Cui K, Liu F, Sun H, Zhang W, Ye Y, Qiao F, Wang J, Ning CZ, Chang-Hasnain CJ, Huang Y.   +14 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

High-resolution Hi-C profiling of human breast tissues using an optimized protocol for clinical samples. [PDF]

STAR Protoc
Choppavarapu L, Fang K, Eacker S, Langford K, Rader JS, Jin VX.   +5 more
europepmc   +1 more source

Beade

, 1993
La publicación describe los aspectos geográficos, socioeconómicos y patrimoniales más significativos que presenta el municipio orensano de Beade, que ocupa una posición central dentro de la conocida comarca vitivinícola del Ribeiro y cuyo territorio, en el que predominan los viñedos, presenta unas tierras de valle drenadas por el río Avia, que bordea ...
openaire   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Survival Behavior of <i>Lactobacillus plantarum</i> Loaded in Alginate/Konjac Glucomannan Composite Beads Under Storage and Gastrointestinal Conditions. [PDF]

Food Sci Nutr
Chen W, Zhao K, Zang J, Hao R, Liu B, Du H, Xu W.   +6 more
europepmc   +1 more source

Bead [PDF]

, 2020
openaire   +1 more source