Results 121 to 130 of about 6,823,654 (239)
, 1975 beak nThis hen, she had dozens of nephews and cousins, The universe round I would roam for her sake. But some wicked creature in form and in feature He lifted my pullet to sharpen his beak.
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Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo
Advanced Science, EarlyView.As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao +12 more
wiley +1 more source
Advanced Science, EarlyView.Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou +6 more
wiley +1 more source
Watershed management model for Lake Simcoe
, 1994 In 1990 the implementation phase of the LSEMS program was initiated. As part of the implementation program, development of a water quality management model was proposed.
Walker, Robert R., McDougal, Sandra
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The National Treatment Purchase Fund: treating people faster.
, 2006 The National Treatment Purchase Fund (NTPF) was set up by the Government to treat patients like you, who have been longest on public hospital waiting lists for an operation.
National Treatment Purchase Fund
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Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape
Advanced Science, EarlyView.Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim +12 more
wiley +1 more source
Advanced Science, EarlyView.This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen +9 more
wiley +1 more source
Advanced Science, EarlyView.An optimized Cas9‐enriched nanopore sequencing workflow, combined with STRiker, enables simultaneous analysis of disease‐associated STR loci from patient blood. The nCATS–STRiker workflow detects repeat expansions, de novo repeat motifs, interruption patterns, and methylation in a single assay, improving the genetic diagnosis of previously undiagnosed ...
Seungbok Lee +11 more
wiley +1 more source
Beak trimming reduces feeding efficiency of hens
, 2004 The ability of beak-trimmed and intact laying hens to ingest feed pellets was examined by highspeed video filming of feeding birds. The birds were exposed to either a deep layer of pellets or a single layer of pellets.
Prescott, N. B., Bonser, R. H. C.
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, 1978 beak nIt has been recommended.. that I take up some form of exercise..I believe I'll exercise my beak. It's not too strenuous and about my speed. I'm reading the book "Ten Easy Steps to a More Powerful Proboscis."PRINTED ITEM DNE-citGMS May ...
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