Results 141 to 150 of about 6,123 (278)

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

Two Curlew Sandpipers Use Their Beaks to Forage for Food

, 2000
Two curlew sandpipers forage for food at the Okaloosa County Sewage Ponds in Fort Walton Beach by submerging their beaks to peck at small insects.https://digitalcommons.usf.edu/fos_images/2444/thumbnail ...
Blakeburn, Paul
core  

Stick dexterity in carrion crows. [PDF]

Learn Behav
Sugasawa S.
europepmc   +1 more source

Optimized Cas9‐Enriched Nanopore Sequencing and Analysis Workflow for Clinical Diagnosis of Repeat Expansion Disorders

Advanced Science, EarlyView.
An optimized Cas9‐enriched nanopore sequencing workflow, combined with STRiker, enables simultaneous analysis of disease‐associated STR loci from patient blood. The nCATS–STRiker workflow detects repeat expansions, de novo repeat motifs, interruption patterns, and methylation in a single assay, improving the genetic diagnosis of previously undiagnosed ...
Seungbok Lee, Chanju Jung, Minjeong Kim, Narae Kim, Gue‐Ho Hwang, Soon‐Tae Lee, Kon Chu, Sang Kun Lee, Han‐Joon Kim, Jong‐Hee Chae, Sangsu Bae, Jangsup Moon   +11 more
wiley   +1 more source

A yellow warbler is for the climate as a canary is for the coal mine. [PDF]

Proc Natl Acad Sci U S A
Grant PR.
europepmc   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Inhibition of either the sympathetic or parasympathetic nervous system increases tonic immobility duration in laying hens. [PDF]

Poult Sci
von Seggern IC, Sutherland HL, Erasmus MA, Fraley GS.   +3 more
europepmc   +1 more source

Interfacial Interaction‐Engineered Dual Lithiophilic Ultrathin Interlayers for Dendrite‐Suppressed Lithium Metal Textile Anodes

Advanced Science, EarlyView.
Ultrathin lithiophilic interlayers engineered on a 3D textile electrode and separator cooperatively regulate interfacial Li nucleation and Li+ transport, leading to homogeneous Li plating and mitigated dendrite formation. The resulting dual‐interfacial design provides long‐term cycling stability, improved full‐cell durability, and a scalable pathway ...
Chanseok Lee, Donghyeon Nam, Sang Hun Baeck, Boyeon Kim, Yongkwon Song, Jaemin Kim, Daegun Kim, Jun Hyuk Moon, Yoon Jang Chung, Hyeong Jun Kim, Seoin Back, Yongmin Ko, Jinhan Cho   +12 more
wiley   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

Corrigendum: The significance of cephalopod beaks as a research tool: An update

Frontiers in Physiology, 2023
José C. Xavier, José C. Xavier, Alexey V. Golikov, José P. Queirós, José P. Queirós, Catalina Perales-Raya, Rigoberto Rosas-Luis, José Abreu, José Abreu, Giambattista Bello, Paco Bustamante, Paco Bustamante, Juan C. Capaz, Valerie H. Dimkovikj, Ángel F. González, Hugo Guímaro, Hugo Guímaro, Airam Guerra-Marrero, José N. Gomes-Pereira, Jorge Hernández-Urcera, Tsunemi Kubodera, Vladimir Laptikhovsky, Evgenia Lefkaditou, Fedor Lishchenko, Amanda Luna, Bilin Liu, Graham J. Pierce, Vasco Pissarra, Elodie Reveillac, Evgeny V. Romanov, Rui Rosa, Marjorie Roscian, Lisa Rose-Mann, Isabelle Rouget, Pilar Sánchez, Antoni Sánchez-Márquez, Sónia Seixas, Sónia Seixas, Louise Souquet, Jaquelino Varela, Erica A. G. Vidal, Yves Cherel   +41 more
doaj   +1 more source