Results 21 to 30 of about 217,547 (269)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Design of ion beam source for a sample tokamak neutral beam injection heating system [PDF]

مجله علوم و فنون هسته‌ای, 2020
In this paper, the design and simulation of ion source based on a helicon plasma generator and its corresponding extraction system for design of the neutral beam injection heating system of a sample tokamak like Damavand tokamak using COMSOL software ...
S. Fazelpour, A. Chakhmachi, H. Sadeghi
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Emittance of a Low-Power RF Ion Source with a Micrometer-Scale Extraction Aperture

East European Journal of Physics
The concept of a compact nuclear microprobe is based on specialized ion sources with beam currents not exceeding a few nanoamperes and a small energy spread.
Vitalii I. Voznyi, Aleksandr G. Ponomarev, Dmytro V. Mahilin, Dmytro P. Shulha, Volodymyr A. Rebrov   +4 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Beam stripping interactions in compact cyclotrons

Physical Review Accelerators and Beams, 2021
Beam stripping losses of H^{-} ion beams by interactions with residual gas and electromagnetic fields are evaluated. These processes play an important role in compact cyclotrons where the beam is produced on an internal ion source, and they operate under
P. Calvo, I. Podadera, D. Gavela, C. Oliver, A. Adelmann, J. Snuverink, A. Gsell   +6 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Investigation of the electrostatic focusing of beams of electrosprayed nanodroplets for microfabrication applications

AIP Advances, 2019
This article presents a focused electrospray beam source and discusses its potential for microfabrication. Its main elements are an electrospray emitter electrode (a point source of charged nanodroplets), an extractor electrode, a skimmer electrode, and ...
Elham Vakil Asadollahei, Manuel Gamero-Castaño   +1 more
doaj   +1 more source

Semiempirical zero-dimensional approach for the estimation of beam features from plasma parameters in proton sources

Physical Review Accelerators and Beams, 2020
Beam intensity, proton fraction, and beam emittance represent the most important characteristics of a beam extracted by a proton source. Beam parameters are strongly related to the parameters of the plasma from which the beam is extracted.
G. Castro
doaj   +1 more source