Results 41 to 50 of about 300,283 (196)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Plastic rotation capacity of lightweight-aggregate concrete beams

Journal of Civil Engineering and Management, 2016
This article describes a study on the plastic behaviour of lightweight-aggregate concrete beams. The experimental results of nineteen simply supported beams previously tested by the authors were used in this study.
Luís F. A. Bernardo, Miguel C. S. Nepomuceno, Hugo A. S. Pinto   +2 more
doaj   +1 more source

Low-dimensional non-metal catalysts: principles for regulating p-orbital-dominated reactivity

npj Computational Materials, 2021
Activation of p-block elements to replace the rare and precious transition metals for renewable energy applications is highly desirable. In this review, we go over recent experimental and theoretical progress on the low-dimensional non-metal materials ...
Si Zhou, Wei Pei, Yanyan Zhao, Xiaowei Yang, Nanshu Liu, Jijun Zhao   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Enhanced production of 60Fe in massive stars

Nature Communications
Massive stars are a major source of chemical elements in the cosmos, ejecting freshly produced nuclei through winds and core-collapse supernova explosions into the interstellar medium.
A. Spyrou, D. Richman, A. Couture, C. E. Fields, S. N. Liddick, K. Childers, B. P. Crider, P. A. DeYoung, A. C. Dombos, P. Gastis, M. Guttormsen, K. Hermansen, A. C. Larsen, R. Lewis, S. Lyons, J. E. Midtbø, S. Mosby, D. Muecher, F. Naqvi, A. Palmisano-Kyle, G. Perdikakis, C. Prokop, H. Schatz, M. K. Smith, C. Sumithrarachchi, A. Sweet   +25 more
doaj   +1 more source

Layer-dependent magnetic phase diagram in Fe n GeTe2 (3 ≤ n ≤ 7) ultrathin films

Communications Physics, 2022
2D magnetism offers the prospect of ordered and controllable magnetic states at reduced dimensions and there is a desire to obtain materials which can realise these properties at room temperature.
Qinxi Liu, Jianpei Xing, Zhou Jiang, Yu Guo, Xue Jiang, Yan Qi, Jijun Zhao   +6 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Buckling analysis of thin-walled functionally graded sandwich box beams [PDF]

, 2015
Buckling analysis of thin-walled functionally graded (FG) sandwich box beams is investigated. Material properties of the beam are assumed to be graded through the wall thickness.
Lee, Jaehong, Domagoj Lanc, Vo, Thuc, Jaehong Lee, Lanc, Domagoj, Turkalj, Goran, Thuc P. Vo, Goran Turkalj   +7 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source