Results 151 to 160 of about 475,810 (306)
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Bowman Dairy Company mascot "Bud Bowman" and "Big Bear" photograph
, 1930 Bowman Dairy Company mascot "Bud Bowman" and "Big Bear" standing outside the Buckeye Premium Stamp Redemption Center, Big Bear Store #1, Lane Avenue, Columbus, Ohio. The Lane Avenue store, which opened in 1934, was the first Big Bear store and the first
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Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Wayne E. Brown at Toledo Big Bear location
, 1950 Wayne E. Brown at toledo big bear location. In 1934, an innovation in food retailing was introduced in Columbus when Wayne E. Brown opened the first self-service supermarket in central Ohio. The name “Big Bear” was chosen because Brown felt it was catchy
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High-energy, high-fat lifestyle challenges an Arctic apex predator, the polar bear
Science, 2018 A. M. Pagano +9 more
semanticscholar +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Photograph of cattle at Big Bear Farms
, 1962 Black and white photograph of cattle and Big Bear stores President, Wayne E. Brown, at Big Bear Farms in Powell, Ohio. Big Bear Farms provided a good portion of the meats offered by the self service Big Bear chain stores. The farm was located near Powell,
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Dairy case at the Graceland Shopping Center Big Bear location
, 1954 Color photograph of the dairy case at the Graceland Big Bear location in July of 1954. Supermarkets introduced many 'firsts' in the ratailing industry to their customers during these years: one-step shopping; new merchandising gimmicks; many new ...
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Proceedings of the National Academy of Sciences of the United States of America, 2017 Andrea Benazzo +26 more
semanticscholar +1 more source