Results 121 to 130 of about 1,478,908 (297)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Modal Analysis of the Rotor-Journal Bearing System of Rotary Compressor [PDF]
, 2012 In the rotary compressor, the rolling piston and the contacted rotor-journal bearing system are basically moving components. Because of the inertia forces and the periodically changing gas force acting on the rolling piston and the rotor, the journal ...
Feng, Quanke +3 more
core
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Journal bearing lubrication monitoring based on spectrum cluster analysis of vibration signals [PDF]
, 2015 Journal bearings are critical components for many important machines. Lubrication analysis techniques are often not timely and cost effective for monitoring journal bearings.
Gu, Fengshou +4 more
core +2 more sources
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Static, dynamic and levitation characteristics of squeeze film air journal bearing: Designing, modelling, simulation and fluid solid interaction [PDF]
, 2011 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Bearings today need to be able to run at very high speed, providing high positional accuracy for the structure that it supports, and requiring very little ...
Wang, Chao
core +2 more sources
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
LubricantsCarbon quantum dots (CQDs) have already demonstrated their utility as lubricant additives, and non-contact temperature sensing based on CQDs offers considerable potential for condition monitoring in mechanical, electrical, and other fields, as well as ...
Jiannan Sun +5 more
doaj +1 more source